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[与结缔组织病相关的间质性肺疾病:诊断与治疗方法]

[Interstitial lung disease associated with connective tissue diseases: diagnosis and treatment approaches].

作者信息

Kar Kurt Özlem, Pamuk Ömer Nuri, Kurt Bahar

机构信息

Department of Chest Diseases, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.

出版信息

Tuberk Toraks. 2012;60(4):393-400. doi: 10.5578/tt.3486.

Abstract

Connective tissue diseases are a diverse group of immunologically mediated systemic disorders that often lead to thoracic changes. There are huge differences between epidemiological studies depending upon method of ascertainment and selection criteria regarding the incidence of respiratory involvement due to connective tissue diseases. However, increased mortality and morbidity develops pulmonary involvement due to connective tissue diseases. Interstitial lung disease constitute an important group in this respect and it is estimated that the overall incidence of 15%. Today, still diagnosis, treatment, follow-up, prognosis of IInterstitial lung disease due to Connective tissue diseases (CTD-ILD) related clinical problems have been experienced. The diagnostic methods of disease include clinical approach, pulmonary function tests, high-resolution computed tomography, bronchoalveolar lavage and surgical lung biopsy. Treatment and selection of drugs are still controversial. In this review, a CTD-ILD, separately for each diagnosis, pulmonary function tests and radiological features, prognosis and treatment approaches were evaluated.

摘要

结缔组织病是一组多样的免疫介导的全身性疾病,常导致胸部改变。由于结缔组织病导致的呼吸受累发生率,不同的流行病学研究在确定方法和选择标准上存在巨大差异。然而,结缔组织病导致的肺部受累会增加死亡率和发病率。间质性肺病在这方面是一个重要的类别,据估计总体发病率为15%。如今,由于结缔组织病相关间质性肺病(CTD-ILD)的临床问题,在诊断、治疗、随访和预后方面仍存在困难。疾病的诊断方法包括临床方法、肺功能测试、高分辨率计算机断层扫描、支气管肺泡灌洗和外科肺活检。药物的治疗和选择仍存在争议。在本综述中,针对每种诊断分别评估了CTD-ILD的肺功能测试和放射学特征、预后及治疗方法。

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