Wang Xin-gang, Feng Zhan-zeng, Guo Ming-feng, Han Chun-mao
Department of Burns, the Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou 310009, China.
Zhonghua Shao Shang Za Zhi. 2012 Oct;28(5):374-7.
Rapid angiogenesis is one of the major issues in the field of tissue engineering, and it is an urgent problem to be solved. The process and related mechanism of angiogenesis have been deeply researched. Meanwhile, various methods or strategies for promoting angiogenesis, involving the application of stem cells and growth factors, and construction and modification of biomaterial scaffolds, have also been reported. On one hand, many remarkable advances in the field of promoting angiogenesis have been achieved; on the other hand, the complexity of mechanism and regulation of angiogenesis have gradually been recognized and emphasized. This paper presents a comprehensive overview of advances in research of the strategies for promoting angiogenesis in the field of tissue engineering.
快速血管生成是组织工程领域的主要问题之一,也是亟待解决的紧迫问题。血管生成的过程及相关机制已得到深入研究。同时,也报道了多种促进血管生成的方法或策略,包括干细胞和生长因子的应用以及生物材料支架的构建与修饰。一方面,促进血管生成领域已取得许多显著进展;另一方面,血管生成机制和调控的复杂性也逐渐得到认识和强调。本文全面综述了组织工程领域促进血管生成策略的研究进展。