Department of Pediatrics, Surgery and Bioengineering, Penn State Hershey Pediatric Cardiovascular Research Center, Penn State Hershey Children's Hospital, Hershey, PA 17033-0850, USA.
Artif Organs. 2013 Jan;37(1):37-47. doi: 10.1111/aor.12015.
A novel pulsatile rotary flow pump has been used in clinical extracorporeal life support (ECLS) in Europe. The objective of this study is to evaluate the Medos Deltastream DP3 diagonal pump (Medos Medizintechnik AG, Stolberg, Germany) in a simulated pediatric ECLS system. The ECLS circuit consisted of a Medos Hilite 800LT hollow fiber membrane oxygenator (Medos Medizintechnik AG), a Medos Deltastream DP3 diagonal pump, a 10Fr Terumo TenderFlow Pediatric Arterial Cannula (Terumo Corporation, Tokyo, Japan), and an arterial/venous tubing. All trials were conducted at flow rates ranging from 200-800 mL/min (in 200 mL/min increments) under a blood temperature of 35°C using human blood (hematocrit 40%). The postcannula pressure was maintained 60 mm Hg by a Hoffman clamp. Real-time pressure and flow data were recorded using a Labview-based acquisition system (National Instruments, Austin, TX, USA). The results showed that the Medos Deltastream DP3 can generate effective pulsatile flow without backflow, provide higher flow rates and pressures than nonpulsatile flow, and then create surplus hemodynamic energy and more total hemodynamic energy than nonpulsatile flow. Pulsatility increased with increased speed differential values and flow rates, while the oxygenator pressure drop increased at an acceptable level. The Medos Deltastream DP3 diagonal pump can provide adequate quality of pulsatility without backflow, and generate more hemodynamic energy under pulsatile mode in a simulated pediatric ECLS system.
一种新型脉动旋转流泵已在欧洲的临床体外生命支持（ECLS）中使用。本研究的目的是在模拟儿科 ECLS 系统中评估 Medos Deltastream DP3 对角泵（Medos Medizintechnik AG，德国斯托尔贝格）。ECLS 回路由 Medos Hilite 800LT 空心纤维膜式氧合器（Medos Medizintechnik AG）、Medos Deltastream DP3 对角泵、10Fr Terumo TenderFlow 儿科动脉插管（Terumo Corporation，东京，日本）和动脉/静脉管组成。所有试验均在 35°C 血液温度下以 200-800 mL/min（以 200 mL/min 的增量）的流速进行，使用 40%的人血（血细胞比容）。使用 Hoffman 夹将管后压力维持在 60 mmHg。使用基于 Labview 的采集系统（美国德克萨斯州奥斯汀的 National Instruments）实时记录压力和流量数据。结果表明，Medos Deltastream DP3 可以产生有效的无反流脉动流，提供比非脉动流更高的流速和压力，然后产生多余的血液动力学能量和比非脉动流更多的总血液动力学能量。脉动性随着速度差和流速的增加而增加，而氧合器压降增加在可接受的水平。Medos Deltastream DP3 对角泵可以在不反流的情况下提供足够的脉动质量，并在模拟儿科 ECLS 系统中以脉动模式产生更多的血液动力学能量。
