利妥昔单抗维持治疗后出现严重巨细胞病毒并发症。
Severe CMV complication following maintenance therapy with rituximab.
作者信息
Le Clech Lenaïg, Ianotto Jean-Christophe, Quintin-Roue Isabelle, Tempescul Adrian
机构信息
Department of Clinical Haematology, Institute of Cancerology and Hematology, University Hospital Brest, Brest, France.
出版信息
BMJ Case Rep. 2013 Jan 9;2013:bcr2012006672. doi: 10.1136/bcr-2012-006672.
Abstract
Cytomegalovirus (CMV) encephalitis is a rare infection that immunodeficient patients, mainly where HIV-positive, may suffer from. Several cases were described when complications with the treatment with monoclonal antibodies, like rituximab, for malignant lymphomas. We will describe here the case of a patient, who has developed CMV gastritis, then CMV encephalitis after the treatment of a CLL with a chemotherapy and maintenance therapy with rituximab.
摘要
巨细胞病毒（CMV）脑炎是一种罕见的感染，免疫缺陷患者，主要是艾滋病毒呈阳性的患者可能会患上这种疾病。有几例报告描述了恶性淋巴瘤患者在使用单克隆抗体（如利妥昔单抗）治疗时出现的并发症。我们在此将描述一名患者的病例，该患者在接受慢性淋巴细胞白血病（CLL）化疗及利妥昔单抗维持治疗后，先患上了CMV胃炎，随后又患上了CMV脑炎。
相似文献
1
Severe CMV complication following maintenance therapy with rituximab.利妥昔单抗维持治疗后出现严重巨细胞病毒并发症。
BMJ Case Rep. 2013 Jan 9;2013:bcr2012006672. doi: 10.1136/bcr-2012-006672.
2
Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia.氟达拉滨难治性慢性淋巴细胞白血病患者的低剂量阿仑单抗治疗。
Leuk Lymphoma. 2012 Mar;53(3):424-9. doi: 10.3109/10428194.2011.623258. Epub 2012 Jan 5.
3
Addition of granulocyte macrophage colony stimulating factor does not improve response to early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximab.添加粒细胞巨噬细胞集落刺激因子不能改善阿仑单抗和利妥昔单抗早期治疗高危慢性淋巴细胞白血病的反应。
Leuk Lymphoma. 2013 Mar;54(3):476-82. doi: 10.3109/10428194.2012.717276. Epub 2012 Aug 22.
4
Cytomegalovirus colitis and hypo-IgG after rituximab therapy for rheumatoid arthritis.利妥昔单抗治疗类风湿关节炎后发生巨细胞病毒性结肠炎和低丙种球蛋白血症
J Rheumatol. 2011 May;38(5):965-6. doi: 10.3899/jrheum.100818.
5
Updated guidelines on the management of cytomegalovirus reactivation in patients with chronic lymphocytic leukemia treated with alemtuzumab.阿仑单抗治疗慢性淋巴细胞白血病患者巨细胞病毒再激活管理的更新指南。
Clin Lymphoma Myeloma. 2006 Sep;7(2):125-30. doi: 10.3816/CLM.2006.n.049.
6
Single-agent rituximab in treatment-refractory or poor prognosis patients with chronic lymphocytic leukemia.利妥昔单抗单药治疗难治或预后不良的慢性淋巴细胞白血病患者。
Curr Med Res Opin. 2011 Oct;27(10):1987-93. doi: 10.1185/03007995.2011.615307. Epub 2011 Sep 12.
7
Cytomegalovirus viremia during Campath-1H therapy for relapsed and refractory chronic lymphocytic leukemia and prolymphocytic leukemia.在使用Campath-1H治疗复发难治性慢性淋巴细胞白血病和原淋巴细胞白血病期间的巨细胞病毒血症。
Clin Lymphoma. 2002 Sep;3(2):105-10. doi: 10.3816/clm.2002.n.016.
8
Cytomegalovirus gastritis after rituximab treatment in a non-Hodgkn's lymphoma patient.
World J Gastroenterol. 2006 Mar 28;12(12):1978-9. doi: 10.3748/wjg.v12.i12.1978.
9
Lymphocyte recovery is impaired in patients with chronic lymphocytic leukemia and indolent non-Hodgkin lymphomas treated with bendamustine plus rituximab.接受苯达莫司汀联合利妥昔单抗治疗的慢性淋巴细胞白血病和惰性非霍奇金淋巴瘤患者的淋巴细胞恢复受损。
Ann Hematol. 2014 Nov;93(11):1879-87. doi: 10.1007/s00277-014-2135-8. Epub 2014 Jun 21.
10
Rituximab for chronic lymphocytic leukemia.利妥昔单抗治疗慢性淋巴细胞白血病。
Expert Opin Biol Ther. 2012 Apr;12(4):503-15. doi: 10.1517/14712598.2012.665444. Epub 2012 Feb 28.
引用本文的文献
1
Significance of CMV reactivation in non-allogeneic stem cell transplant patients with cancers: experience of single tertiary care cancer institute.巨细胞病毒再激活在非异基因造血干细胞移植癌症患者中的意义：一家三级癌症专科医院的经验
Virusdisease. 2023 Sep;34(3):383-388. doi: 10.1007/s13337-023-00839-6. Epub 2023 Sep 5.
2
Cytomegalovirus infection in patients with malignant lymphomas who have not received hematopoietic stem cell transplantation.未接受造血干细胞移植的恶性淋巴瘤患者的巨细胞病毒感染。
BMC Cancer. 2022 Sep 1;22(1):944. doi: 10.1186/s12885-022-10008-5.
3
Secondary Immunodeficiency in Hematological Malignancies: Focus on Multiple Myeloma and Chronic Lymphocytic Leukemia.血液系统恶性肿瘤中的继发性免疫缺陷：以多发性骨髓瘤和慢性淋巴细胞白血病为例。
Front Immunol. 2021 Oct 25;12:738915. doi: 10.3389/fimmu.2021.738915. eCollection 2021.
4
Peripheral B Cell Deficiency and Predisposition to Viral Infections: The Paradigm of Immune Deficiencies.外周 B 细胞缺陷与病毒感染易感性：免疫缺陷的范例。
Front Immunol. 2021 Aug 30;12:731643. doi: 10.3389/fimmu.2021.731643. eCollection 2021.
5
Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies.生物制剂和小分子靶向免疫调节治疗的感染并发症。
Clin Microbiol Rev. 2020 Jun 10;33(3). doi: 10.1128/CMR.00035-19. Print 2020 Jun 17.
6
Cytomegalovirus in the neonate: immune correlates of infection and protection.新生儿巨细胞病毒感染：感染与保护的免疫关联
Clin Dev Immunol. 2013;2013:501801. doi: 10.1155/2013/501801. Epub 2013 Aug 19.
本文引用的文献
1
Regulatory B cells play a key role in immune system balance.调节性 B 细胞在免疫系统平衡中发挥着关键作用。
Joint Bone Spine. 2013 Jan;80(1):18-22. doi: 10.1016/j.jbspin.2012.04.010. Epub 2012 Jul 31.
2
Does rituximab increase the incidence of infectious complications? A narrative review.利妥昔单抗是否会增加感染并发症的发生率？一篇叙述性综述。
Int J Infect Dis. 2011 Jan;15(1):e2-16. doi: 10.1016/j.ijid.2010.03.025. Epub 2010 Nov 11.
3
Rituximab-associated infections.利妥昔单抗相关感染。
Semin Hematol. 2010 Apr;47(2):187-98. doi: 10.1053/j.seminhematol.2010.01.002.
4
Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet.接受西多福韦和膦甲酸钠联合治疗成功的异基因造血干细胞移植受者的巨细胞病毒性脑炎/视网膜炎
Pediatr Transplant. 2009 Nov;13(7):919-22. doi: 10.1111/j.1399-3046.2008.01070.x. Epub 2008 Nov 1.
5
Rituximab-related viral infections in lymphoma patients.淋巴瘤患者中与利妥昔单抗相关的病毒感染
Leuk Lymphoma. 2007 Jul;48(7):1307-12. doi: 10.1080/10428190701411441.
6
Cytomegalovirus ventriculoencephalitis in a peripheral blood stem cell transplant recipient.一名外周血干细胞移植受者发生巨细胞病毒性脑室脑炎。
Clin Infect Dis. 2006 Feb 15;42(4):e26-9. doi: 10.1086/499366. Epub 2006 Jan 6.
7
Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia.氟达拉滨、环磷酰胺和利妥昔单抗化疗免疫疗法作为慢性淋巴细胞白血病初始治疗的早期结果。
J Clin Oncol. 2005 Jun 20;23(18):4079-88. doi: 10.1200/JCO.2005.12.051. Epub 2005 Mar 14.
8
Definitions of cytomegalovirus infection and disease in transplant recipients.移植受者中巨细胞病毒感染和疾病的定义。
Clin Infect Dis. 2002 Apr 15;34(8):1094-7. doi: 10.1086/339329. Epub 2002 Mar 11.
9
Fatal reactivation of cytomegalovirus infection after use of rituximab for a post-transplantation lymphoproliferative disorder.使用利妥昔单抗治疗移植后淋巴增殖性疾病后巨细胞病毒感染的致命再激活。
N Engl J Med. 2001 Sep 27;345(13):1000. doi: 10.1056/NEJM200109273451315.
Zotero 插件