Department of surgery, Medical University of Erlangen/Nuremberg, Erlangen, Germany.
Adv Med Sci. 2012;57(2):259-65. doi: 10.2478/v10039-012-0052-4.
In the literature, the manifestations of gastric cancer have been described based on all patients. In recent times, interest has focused on the subgroup of young patients. In the following analysis, the subgroup of young patients (< 50y) is compared with an older reference group (≥ 50y).
Between 01.01.1995 and 31.12.2005, 482 patients with a previously untreated gastric cancer underwent surgery. Fifty-six patients in this group were under 50 years of age, and the remaining 367 patients constituted the reference group. All data were recorded prospectively and analyzed retrospectively from the clinical cancer registry of the University of Erlangen.
The analysis showed that the young patients had a similar tumor stage distribution. Diffuse tumor stages in the Laurén classification occurred significantly more often. The postoperative complication rate was similar, but the hospital mortality rate was significantly lower. The young patients had an obvious, but not significant, 5-year survival advantage in all tumor stages.
Younger patients can be operated on with greater confidence as they have a significantly lower hospital mortality rate. They exhibit markedly better 5-year survival at all tumor stages. According to our data, there is nothing to support the general belief that young patients have a poorer disease course. Further clinical and experimental studies are necessary to investigate this group more precisely.
在文献中，胃癌的表现是基于所有患者描述的。最近，人们对年轻患者亚组的兴趣有所增加。在下面的分析中，将年轻患者亚组（<50 岁）与较年长的参考组（≥50 岁）进行比较。
1995 年 1 月 1 日至 2005 年 12 月 31 日，482 例未经治疗的胃癌患者接受了手术。该组中有 56 例患者年龄小于 50 岁，其余 367 例患者构成参考组。所有数据均从埃尔朗根大学的临床癌症登记处前瞻性记录并回顾性分析。
分析表明，年轻患者的肿瘤分期分布相似。弥漫型肿瘤分期在劳伦分类中更为常见。术后并发症发生率相似，但医院死亡率明显较低。在所有肿瘤分期中，年轻患者的 5 年生存率明显但无统计学意义更高。
年轻患者可以更有信心地接受手术，因为他们的医院死亡率明显较低。他们在所有肿瘤分期中都表现出明显但无统计学意义的 5 年生存率优势。根据我们的数据，没有任何证据支持一般认为年轻患者疾病进程较差的观点。需要进一步的临床和实验研究来更精确地研究这一组。
