上皮细胞和间充质细胞的集体细胞迁移。
Collective cell migration of epithelial and mesenchymal cells.
机构信息
Department of Cell and Developmental Biology, University College London, London, UK.
出版信息
Cell Mol Life Sci. 2013 Oct;70(19):3481-92. doi: 10.1007/s00018-012-1251-7. Epub 2013 Jan 12.
Abstract
Directional cell migration is required for proper embryogenesis, immunity, and healing, and its underpinning regulatory mechanisms are often hijacked during diseases such as chronic inflammations and cancer metastasis. Studies on migratory epithelial tissues have revealed that cells can move as a collective group with shared responsibilities. First thought to be restricted to proper epithelial cell types able to maintain stable cell-cell junctions, the field of collective cell migration is now widening to include cooperative behavior of mesenchymal cells. In this review, we give an overview of the mechanisms driving collective cell migration in epithelial tissues and discuss how mesenchymal cells can cooperate to behave as a collective in the absence of bona fide cell-cell adhesions.
摘要
定向细胞迁移对于胚胎发生、免疫和愈合是必需的，其潜在的调控机制在慢性炎症和癌症转移等疾病中经常被劫持。对迁移上皮组织的研究表明，细胞可以作为一个具有共同责任的集体群体移动。最初被认为仅限于能够维持稳定细胞-细胞连接的适当上皮细胞类型，集体细胞迁移领域现在正在扩大，包括间质细胞的合作行为。在这篇综述中，我们概述了驱动上皮组织中集体细胞迁移的机制，并讨论了在没有真正细胞-细胞黏附的情况下，间质细胞如何合作表现为一个集体。
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