白细胞介素-1 多态性与三种族裔人群胃癌的相关性。
Associations between interleukin-1 polymorphisms and gastric cancers among three ethnicities.
机构信息
Internal Medicine-Oncology, Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China.
出版信息
World J Gastroenterol. 2012 Dec 21;18(47):7093-9. doi: 10.3748/wjg.v18.i47.7093.
AIM
To investigate the associations between interleukin (IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet, Hui and Han ethnicities.
METHODS
Genomic DNA was extracted from peripheral blood of 210, 205, and 202 healthy volunteers and from 155, 158, and 197 gastric cancer patients from the Tibet, Hui, and Han populations, respectively. Polymorphisms in IL-1B and IL-1RN were analyzed by denaturing high-performance liquid chromatography.
RESULTS
Carriers of the IL-1B-31 CC genotype had an increased risk of intestinal type gastric cancer [odds ratio (OR) = 2.17, P = 0.037] in the Tibet ethnicity. Carriers of the IL-1B 2/L genotype had an increased risk of both intestinal and diffuse types of gastric cancer (OR = 2.08, 2.31, P = 0.007, 0.016, respectively) in the Hui ethnicity. In the Han population, carriers of the IL-1B-31 CC, IL-1B-511CT, TT genotypes had increased risk of intestinal type gastric cancer (OR = 2.51, 2.74, 5.66, P = 0.005, 0.002, 0.000, respectively).
CONCLUSION
IL-1B and IL-RN genotypes may differentially contribute to gastric cancer among the Tibet, Hui, and Han ethnicities in the Qinghai area of China.
目的
探讨白细胞介素（IL）-1B 和 IL-1RN 多态性与藏族、回族和汉族人群胃癌的关系。
方法
从青海地区的 210 名、205 名和 202 名健康志愿者及 155 名、158 名和 197 名藏族、回族和汉族胃癌患者外周血中提取基因组 DNA。采用变性高效液相色谱法分析 IL-1B 和 IL-1RN 多态性。
结果
藏族人群中，IL-1B-31 CC 基因型携带者患肠型胃癌的风险增加（优势比[OR] = 2.17，P = 0.037）。回族人群中，IL-1B 2/L 基因型携带者患肠型和弥漫型胃癌的风险均增加（OR = 2.08、2.31，P = 0.007、0.016）。在汉族人群中，IL-1B-31 CC、IL-1B-511CT、TT 基因型携带者患肠型胃癌的风险增加（OR = 2.51、2.74、5.66，P = 0.005、0.002、0.000）。
结论
IL-1B 和 IL-RN 基因型可能在中国青海地区不同程度地导致藏族、回族和汉族人群胃癌的发生。
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