Department of Pharmaceutical Chemistry, Graduate School of Health Sciences, Anadolu University , Eskisehir , Turkey .
J Enzyme Inhib Med Chem. 2014 Feb;29(1):43-8. doi: 10.3109/14756366.2012.752363. Epub 2013 Jan 17.
In this study, 14 different 2-[(1-methyl-1H-tetrazole-5-yl)thio]-1-(phenyl)ethanone derivatives (1-14) were synthesized. The structures of the obtained compounds were elucidated using IR, (1)H-NMR, (13)C-NMR and FAB(+)-MS spectral data and elemental analyses results. The compounds were screened for their anticandidal activity using the microbroth dilution method and for their cytotoxic effects using the MTT assay against NIH/3T3 cells. Some of the compounds were found to be potent anticandidal agents with weak cytotoxicities.
在这项研究中，合成了 14 种不同的 2-[(1-甲基-1H-四唑-5-基)硫基]-1-(苯基)乙酮衍生物（1-14）。使用红外光谱（IR）、（1）H-NMR、（13）C-NMR 和 FAB(+)-MS 光谱数据以及元素分析结果阐明了所得化合物的结构。使用微量稀释法筛选化合物的抗真菌活性，并使用 MTT 测定法测定化合物对 NIH/3T3 细胞的细胞毒性。一些化合物被发现具有潜在的抗真菌活性，同时细胞毒性较弱。
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