Tsukanov Iu T, Tsukanov A Iu, Nikolaĭchuk A I
Angiol Sosud Khir. 2012;18(4):59-63.
The study was aimed at determining the dynamics of saphenous veins in patients with varicophlebitis of the great saphenous vein (GSV) in a subacute period (during compression therapy) and at assessing efficacy of 4-month medicamentous protection thereof. We examined a total of 32 patients presenting with the first episode of non-embolic varicophlebitis of the great saphenous vein. The comparison group comprised 16 patients undergoing 4-month compression (degree 2) therapy alone, and the study group patients (n = 16) were subjected to compression therapy combined with a 4-month course of micronized diosmin (1 tablet twice a day). The patients were included into the groups alternately as they attended our medical facility. Duplex scanning before and after the treatment course was used to measure the following parameters: 1) the evening diameter of veins and 2) an increase in the vein's diameter measured overnight as compared to the morning measures - the orthostatic gradient. The obtained results showed that the subacute period of varicophlebitis of the GSV is accompanied and followed by an increase in the diameter of the GSV and SSV and that of their orthostatic gradient, caused by imparted tonicity and viscoelastic properties. Compression therapy alone in the subacute period of varicophlebitis does not provide complete safety of saphenous veins from secondary lesions. Compression therapy combined with a 4-month-long course of taking micronized diosmin increases the efficacy of treatment.
该研究旨在确定大隐静脉曲张（GSV）亚急性期（在压迫治疗期间）患者大隐静脉的动态变化，并评估对其进行4个月药物保护的疗效。我们共检查了32例首次发生大隐静脉非栓塞性静脉曲张的患者。对照组由16例仅接受4个月压迫（2级）治疗的患者组成，研究组患者（n = 16）接受压迫治疗并联合服用4个月的微粒化地奥司明（每日2次，每次1片）。患者到我们医疗机构就诊时交替分组。治疗前后采用双功扫描测量以下参数：1）静脉的夜间直径；2）与早晨测量值相比，夜间测量的静脉直径增加量——直立梯度。获得的结果表明，大隐静脉曲张的亚急性期伴随着大隐静脉和小隐静脉直径及其直立梯度的增加，这是由赋予的张力和粘弹性特性引起的。在静脉曲张亚急性期单独进行压迫治疗不能完全保障隐静脉免受继发性病变的影响。压迫治疗联合服用4个月微粒化地奥司明可提高治疗效果。
