Laboratory of Organic and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Molecules. 2013 Jan 16;18(1):1162-73. doi: 10.3390/molecules18011162.
Synthesis of beneficial protected meso-DAP 9 by cross metathesis of the Garner aldehyde-derived vinyl glycine 1b with protected allyl glycine 2 in the presence of Grubbs second-generation catalyst was performed. Preparation of lipophilic N-acyl iE-DAP as potent agonists of NOD 1-mediated immune response from 9 is described.
在 Grubbs 第二代催化剂的存在下,通过 Garner 醛衍生的乙烯基甘氨酸 1b 与保护的烯丙基甘氨酸 2 的交叉复分解反应,合成了有益的保护 meso-DAP9。描述了从 9 制备亲脂性 N-酰基 iE-DAP,作为 NOD1 介导的免疫反应的有效激动剂。