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[因前列腺癌复发而行扩大挽救性盆腔及腹膜后淋巴结清扫术]

[Extended salvage pelvic and retroperitoneal lymph node dissection due to prostate cancer relapse].

作者信息

Osmonov D K, Aksenov A V, Jünemann K-P

机构信息

Klinik für Urologie und Kinderurologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel.

出版信息

Aktuelle Urol. 2013 Jan;44(1):50-2. doi: 10.1055/s-0032-1333239. Epub 2013 Jan 16.

Abstract

Treatment of a biochemical prostate cancer relapse represents a difficult clinical dilemma, which has remained without a definitive solution so far. Based on clinical studies, we combine radical prostatectomy with extended pelvic lymph node dissection in intermediate and high risk patients as a routine procedure at our clinic. In this paper, we report on a case of extended salvage lymphadenectomy performed due to biochemical prostate cancer recurrence. The 56-year-old patient came to our clinic in April 2012 with a finding of lymph node metastasis according to PET-CT imaging. Laparoscopic radical retropubic prostatectomy with lymphadenectomy had been performed in 2008 [pT3a, N0 (0/4), M0, R0, GS 5+4=9, iPSA 26.67 ng/mL], and followed by radiotherapy as of September 2009. The extended salvage lymphadenectomy was performed in April 2012 due to a PSA-level rise up to 24 ng/mL and the aforementioned PET-CT findings. A total of 22 lymph nodes were removed, among them 3 lymph nodes with metastases. In the fossa obturatoria on the right we identified a walnut-size lymph node relapse with tumour necrosis, which fully corresponded to the PET-CT scan. The PSA level subsequently dropped to 0.4 ng/mL postoperatively, and further to the current value of 0.02 ng/mL (August 2012).

摘要

生化复发型前列腺癌的治疗是一个棘手的临床难题,迄今为止仍未得到明确解决。基于临床研究,我们在诊所将根治性前列腺切除术与扩大盆腔淋巴结清扫术联合用于中高危患者,作为常规手术。在本文中,我们报告了一例因生化复发型前列腺癌而行扩大挽救性淋巴结清扫术的病例。该56岁患者于2012年4月前来我院,根据PET-CT成像发现有淋巴结转移。2008年已行腹腔镜耻骨后根治性前列腺切除术及淋巴结清扫术[pT3a,N0(0/4),M0,R0,GS 5+4=9,iPSA 26.67 ng/mL],并于2009年9月开始接受放疗。由于PSA水平升至24 ng/mL以及上述PET-CT检查结果,于2012年4月进行了扩大挽救性淋巴结清扫术。共切除22个淋巴结,其中3个有转移。在右侧闭孔窝,我们发现一个核桃大小的淋巴结复发伴肿瘤坏死,与PET-CT扫描结果完全相符。术后PSA水平随后降至0.4 ng/mL,进一步降至当前的0.02 ng/mL(2012年8月)。

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