Thejaswini Mu, Padmaja Kp, Srinivasamurthy V, Rao M Sudha
Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bangalore, Karnataka, India.
J Cytol. 2012 Oct;29(4):258-60. doi: 10.4103/0970-9371.103947.
A 30-year-old woman presented with a huge exophytic lobulated mass in the right breast, clinically and radiologically resembling phylloides tumor. Fine needle aspiration cytology smears showed clusters and singly scattered spindle cells along with structures reminiscent of verocay bodies. However, the epithelial elements were absent. A cytological diagnosis of benign mesenchymal spindle cell lesion, suggestive of schwannoma was rendered. Subsequent histopathological examination and strong S-100 positivity of tumor cells on immunohistochemistry confirmed the diagnosis.Breast is an uncommon location for benign schwannoma. The present case describes the unusual clinical picture, highlights cytological features and discusses the differential diagnoses of schwannoma from other benign spindle cells lesions of the breast on cytology smears.
一名30岁女性,右乳出现一个巨大的外生性分叶状肿块,临床和影像学表现类似叶状肿瘤。细针穿刺细胞学涂片显示有成群和成单散在的梭形细胞,以及类似Verocay小体的结构。然而,未见上皮成分。作出了良性间叶性梭形细胞病变的细胞学诊断,提示为神经鞘瘤。随后的组织病理学检查及免疫组化显示肿瘤细胞S-100强阳性,证实了诊断。乳腺是良性神经鞘瘤的罕见发病部位。本病例描述了这一不寻常的临床表现,突出了细胞学特征,并讨论了在细胞学涂片上神经鞘瘤与乳腺其他良性梭形细胞病变的鉴别诊断。