一例因使用阿片类药物治疗非恶性慢性疼痛导致的低促性腺激素性性腺功能减退病例。
A case of hypogonadotropic hypogonadism caused by opioid treatment for nonmalignant chronic pain.
作者信息
Tabuchi Yukiko, Yasuda Tetsuyuki, Kaneto Hideaki, Kitamura Tetsuhiro, Kozawa Junji, Otsuki Michio, Imagawa Akihisa, Nakae Aya, Matsuda Youichi, Uematsu Hironobu, Mashimo Takashi, Shibata Masahiko, Shimomura Iichiro
机构信息
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan.
出版信息
Case Rep Med. 2012;2012:740603. doi: 10.1155/2012/740603. Epub 2012 Dec 25.
We report a case of 42-year-old male patient with hypogonadotropic hypogonadism. He suffered from general fatigue and erectile dysfunction after the treatment with transdermal fentanyl for chronic pain by traffic injury. Endocrine examinations and hormone stimulating tests showed that he had hypogonadotropic hypogonadism. Brain magnetic resonance imaging (MRI) showed no abnormal findings, and he had no past history of accounting for acquired hypogonadotropic hypogonadism. Therefore, his hypogonadism was diagnosed to be caused by opioid treatment. Although opioid-induced endocrine dysfunctions are not widely recognized, this case suggests that we should consider the possibility of endocrine dysfunctions in patients with opioid treatment.
我们报告一例42岁患有低促性腺激素性性腺功能减退的男性患者。他因交通伤导致慢性疼痛接受经皮芬太尼治疗后出现全身乏力和勃起功能障碍。内分泌检查和激素刺激试验显示他患有低促性腺激素性性腺功能减退。脑部磁共振成像（MRI）未发现异常，且他没有可解释获得性低促性腺激素性性腺功能减退的既往史。因此，他的性腺功能减退被诊断为由阿片类药物治疗引起。尽管阿片类药物引起的内分泌功能障碍尚未得到广泛认识，但该病例提示我们应考虑接受阿片类药物治疗的患者出现内分泌功能障碍的可能性。
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