Rush University Medical Center, Department of Behavioral Sciences, 1645 W. Jackson, Suite 400, Chicago, IL 60612, USA.
J Psychosom Res. 2013 Feb;74(2):170-4. doi: 10.1016/j.jpsychores.2012.12.006. Epub 2013 Jan 9.
Weight loss can decrease the severity of obstructive sleep apnea (OSA) in many obese individuals; however, very few studies have investigated the effects of behavioral weight loss interventions for patients with OSA. The aims of this pilot study were to determine the feasibility and initial effects on weight and continuous positive airway pressure (CPAP) use of a brief minimal-contact self-monitoring-based weight loss intervention (SM). An additional aim was to investigate the association between weight loss and CPAP adherence.
Forty obese men and women diagnosed with mild or moderate OSA were randomized to either the SM or an attention-control (AC) condition. SM participants completed daily dietary logs for 6 weeks. Participants were weighed at baseline, post-treatment (6 weeks), and at a 6-week follow up.
Recruitment and retention were good in this study and attrition rates did not differ significantly by group. Intent to treat repeated measures ANOVA indicated a main effect of time (but not group), such that both groups lost weight over time. Pearson r correlations between weight change and CPAP adherence indicated that among SM participants, 6-week weight loss was correlated with CPAP adherence at post-treatment and follow-up, such that SM participants with greater weight loss at 6 weeks had greater CPAP adherence at 6 and 12 weeks.
This study provides initial support for the beneficial effects of a minimal-contact weight loss intervention for patients with obstructive sleep apnea and highlights a possible association between weight loss and CPAP adherence.
减肥可以降低许多肥胖个体阻塞性睡眠呼吸暂停(OSA)的严重程度;然而,很少有研究调查过行为减肥干预对 OSA 患者的影响。本研究的目的是确定基于简单自我监测的简短减肥干预(SM)的可行性和对体重及持续气道正压通气(CPAP)使用的初步效果。另一个目的是调查体重减轻与 CPAP 依从性之间的关系。
40 名被诊断为轻度或中度 OSA 的肥胖男性和女性被随机分配到 SM 或注意力对照组(AC)。SM 参与者在 6 周内每天完成饮食日志。参与者在基线、治疗后(6 周)和 6 周随访时称重。
这项研究的招募和保留情况良好,两组的失访率没有显著差异。意向治疗重复测量方差分析表明,时间存在主要影响(但不受组影响),即两组体重随时间减轻。体重变化与 CPAP 依从性的 Pearson r 相关表明,在 SM 参与者中,6 周体重减轻与治疗后和随访时的 CPAP 依从性相关,即 6 周时体重减轻较大的 SM 参与者在 6 周和 12 周时 CPAP 依从性更高。
这项研究初步支持了针对阻塞性睡眠呼吸暂停患者的简单接触减肥干预的有益效果,并强调了体重减轻与 CPAP 依从性之间可能存在关联。