Department of Medicine, University of Montreal, Montreal, Quebec, Canada; Departamento de Neurologia, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Neurochem Int. 2013 Apr;62(5):796-802. doi: 10.1016/j.neuint.2013.01.009. Epub 2013 Jan 18.
Thiamine (vitamin B1) deficiency, the underlying cause of Wernicke-Korsakoff syndrome, is associated with the development of focal neuronal loss in vulnerable areas of the brain. Although the actual mechanism(s) that lead to the selective histological lesions characteristic of this disorder remain unresolved, oxidative stress has been shown to play a major role in its pathophysiology. In this review, the multifactorial influence of oxidative stress on a variety of processes known to take part in the development of structural lesions in TD including excitotoxicity, neuroinflammation, blood-brain barrier integrity, mitochondrial integrity, apoptosis, nucleic acid function, and neural stem cells will be discussed, and therapeutic strategies undertaken for treating neurodegeneration examined which may have an impact on the future treatment of this important vitamin deficiency.
硫胺素（维生素 B1）缺乏是威尼克-科萨科夫综合征的根本原因，与易受影响的大脑区域神经元丧失有关。虽然导致该疾病特征性选择性组织损伤的实际机制仍未解决，但氧化应激已被证明在其病理生理学中起主要作用。在这篇综述中，将讨论氧化应激对包括兴奋性毒性、神经炎症、血脑屏障完整性、线粒体完整性、细胞凋亡、核酸功能和神经干细胞在内的多种已知参与 TD 结构损伤发展的过程的多因素影响，并检查用于治疗神经退行性变的治疗策略，这些策略可能对这种重要维生素缺乏症的未来治疗产生影响。
