Department of Obstetrics and Gynecology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.
Arch Gynecol Obstet. 2013 Jun;287(6):1125-9. doi: 10.1007/s00404-013-2712-4. Epub 2013 Jan 23.
The role of thyroid function in biochemical markers of first trimester screening has not been assessed. The aim of the present study was to investigate if there were any relation between maternal thyroid hormones and free-beta subunit of human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma protein A (PAPP-A) levels as the biochemical markers of the combined first trimester aneuploidy screening.
375 pregnant women between 11 and 14 weeks of gestation who were offered routine first trimester prenatal aneuploidy screening and whose thyroid hormone levels (Thyroid stimulating hormone (TSH), free and total thyroxine, free and total triiodothyronine, anti thyroid peroxidase antibody) were measured were assessed. Correlation of free-β-hCG and PAPP-A with maternal thyroid hormones was analyzed.
There was no statistically significant correlation between maternal TSH, free and total thyroxine, free and total triiodothyronine, anti-thyroid peroxidase antibodies and free-β-hCG and PAPP-A as biochemical markers of first trimester aneuploidy screening.
Maternal thyroid function does not seem to affect secretion of fβ-hCG and PAPP-A.
甲状腺功能在早孕期筛查的生化标志物中的作用尚未被评估。本研究旨在探讨母体甲状腺激素与游离-β亚基人绒毛膜促性腺激素（fβ-hCG）和妊娠相关血浆蛋白 A（PAPP-A）水平之间是否存在任何关系，因为这些标志物是早孕期联合筛查的生化指标。
对 375 名 11 至 14 周妊娠的孕妇进行了评估，这些孕妇接受了常规的早孕期产前非整倍体筛查，并且测量了她们的甲状腺激素水平（促甲状腺激素（TSH）、游离和总甲状腺素、游离和总三碘甲状腺原氨酸、抗甲状腺过氧化物酶抗体）。分析了游离-β-hCG 和 PAPP-A 与母体甲状腺激素的相关性。
母体 TSH、游离和总甲状腺素、游离和总三碘甲状腺原氨酸、抗甲状腺过氧化物酶抗体与游离-β-hCG 和 PAPP-A 作为早孕期非整倍体筛查的生化标志物之间没有统计学上的显著相关性。
母体甲状腺功能似乎不会影响游离-β-hCG 和 PAPP-A 的分泌。
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