人虹膜基质细胞对单纯疱疹病毒 1 进入的易感性。
Susceptibility of human iris stromal cells to herpes simplex virus 1 entry.
机构信息
Department of Microbiology & Immunology, Midwestern University, Downers Grove, Illinois, USA.
出版信息
J Virol. 2013 Apr;87(7):4091-6. doi: 10.1128/JVI.03235-12. Epub 2013 Jan 23.
Abstract
Ocular herpes simplex virus 1 (HSV-1) infection can lead to multiple complications, including iritis, an inflammation of the iris. Here, we use human iris stroma cells as a novel in vitro model to demonstrate HSV-1 entry and the inflammatory mediators that can damage the iris. The upregulated cytokines observed in this study provide a new understanding of the intrinsic immune mechanisms that can contribute to the onset of iritis.
摘要
单纯疱疹病毒 1（HSV-1）眼部感染可导致多种并发症，包括虹膜炎，即虹膜炎症。在此，我们使用人眼虹膜基质细胞作为一种新型的体外模型，来证明 HSV-1 的进入以及可损伤虹膜的炎症介质。本研究中观察到的上调细胞因子为虹膜炎发病的固有免疫机制提供了新的认识。
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