比较在冠状动脉搭桥术中高渗盐水与生理盐水对细胞因子谱的影响。
Comparison of hypertonic saline versus normal saline on cytokine profile during CABG.
机构信息
Department of Pharmacotherapy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Daru. 2012 Oct 8;20(1):49. doi: 10.1186/2008-2231-20-49.
BACKGROUND AND THE PURPOSE OF THE STUDY
Blood contact with artificial surfaces of the extracorporeal circuit and ischemia-reperfusion injury in CABG with CPB, may lead to a systemic inflammatory response. Hypertonic saline have been recently investigated as a fluid in order to decrease inflammatory response and cytokines generation in patients undergo cardiac operations. Our purpose is to study the prophylactic effect of HS 5% infusion versus NS on serum IL-6 as an inflammatory & IL-10 as an anti-inflammatory biomarker in CABG patients.
METHODS
The present study is a randomized double-blinded clinical trial. 40 patients undergoing CABG were randomized to receive HS 5% or NS before operation. Blood samples were obtained after receiving HS or NS, just before operation, 24 and 48 hours post-operatively. Plasma levels of IL-6 and IL-10 were measured by ELISA.
RESULTS AND MAJOR CONCLUSION
Patients received HS had lower levels of IL-6 and higher level of IL-10 compared with NS group, however these differences were not statistically significant. Results of this study suggest that pre-treatment with small volume hypertonic saline 5% may have beneficial effects on inflammatory response following CABG operation.
背景与研究目的
体外循环中血液与人工表面接触以及 CABG 中的缺血再灌注损伤可能导致全身炎症反应。高渗盐水最近被研究为一种液体，以减少接受心脏手术的患者的炎症反应和细胞因子生成。我们的目的是研究在 CABG 患者中，HS5% 输注与 NS 相比对血清 IL-6（炎症标志物）和 IL-10（抗炎标志物）的预防性作用。
方法
本研究是一项随机双盲临床试验。40 名接受 CABG 的患者被随机分为在手术前接受 HS5%或 NS。在接受 HS 或 NS 后，在手术前、术后 24 小时和 48 小时采集血样。通过 ELISA 测量血浆中 IL-6 和 IL-10 的水平。
结果和主要结论
与 NS 组相比，接受 HS 的患者的 IL-6 水平较低，IL-10 水平较高，但这些差异无统计学意义。本研究结果表明，在 CABG 手术后，小体积高渗盐水 5% 的预处理可能对炎症反应有有益的影响。
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