TRPM7 通过 MAPK 通路介导乳腺癌细胞迁移和侵袭。
TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway.
机构信息
Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China.
出版信息
Cancer Lett. 2013 Jun 1;333(1):96-102. doi: 10.1016/j.canlet.2013.01.031. Epub 2013 Jan 23.
Metastasis is an inherent feature of breast cancer and transient receptor potential (TRP) channels were found to be potentially implicated in this process. Particularly, TRPM7 may regulate cell motility. We therefore examined the expression of TRPM7 mRNA in the Oncomine database and found that TRPM7 is correlated to metastasis and invasive breast cancer. Silencing TRPM7 with RNA interference resulted in a significant decrease in migration and invasion capability of MDA-MB-435 breast cancer cells, and phosphorylation levels of Src and MAPK but not AKT. Our results suggest that TRPM7 regulates migration and invasion of metastatic breast cancer cells via MAPK pathway.
转移是乳腺癌的固有特征，瞬时受体电位 (TRP) 通道被发现可能与这一过程有关。特别是，TRPM7 可能调节细胞运动。因此，我们在 Oncomine 数据库中检查了 TRPM7 mRNA 的表达，发现 TRPM7 与转移和浸润性乳腺癌相关。用 RNA 干扰沉默 TRPM7 导致 MDA-MB-435 乳腺癌细胞的迁移和侵袭能力显著降低，以及 Src 和 MAPK 的磷酸化水平降低，但 AKT 没有变化。我们的结果表明，TRPM7 通过 MAPK 通路调节转移性乳腺癌细胞的迁移和侵袭。
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