Division of Cardiovascular & Diabetes Medicine, Medical Research Institute, College of Medicine Dentistry & Nursing, University of Dundee, Dundee DD1 9SY, UK.
Biochem Soc Trans. 2013 Feb 1;41(1):95-100. doi: 10.1042/BST20120269.
The Na+/K+-ATPase (Na+ pump) is the principal consumer of ATP in multicellular organisms. In the heart, the Na+ gradient established by the pump is essential for all aspects of cardiac function, and appropriate regulation of the cardiac Na+ pump is therefore crucial to match cardiac output to the physiological requirements of an organism. The cardiac pump is a multi-subunit enzyme, consisting of a catalytic α-subunit and regulatory β- and FXYD subunits. All three subunits may become palmitoylated, although the functional outcome of these palmitoylation events is incompletely characterized to date. Interestingly, both β- and FXYD subunits may be palmitoylated or glutathionylated at the same cysteine residues. These competing chemically distinct post-translational modifications may mediate functionally different effects on the cardiac pump. In the present article, we review the cellular events that control the balance between these modifications, and discuss the likely functional effects of pump subunit palmitoylation.
Na+/K+-ATP 酶（钠泵）是多细胞生物中消耗 ATP 的主要酶。在心脏中，泵建立的钠离子梯度对心脏功能的各个方面都至关重要，因此适当调节心脏钠泵对于使心输出量与机体的生理需求相匹配至关重要。心脏泵是一种多亚基酶，由催化α亚基和调节β-和 FXYD 亚基组成。所有三个亚基都可能发生棕榈酰化，但迄今为止，这些棕榈酰化事件的功能结果还不完全清楚。有趣的是，β-和 FXYD 亚基都可能在相同的半胱氨酸残基上发生棕榈酰化或谷胱甘肽化。这些具有竞争性的化学不同的翻译后修饰可能对心脏泵产生功能不同的影响。在本文中，我们回顾了控制这些修饰之间平衡的细胞事件，并讨论了泵亚基棕榈酰化的可能功能影响。
