急性肝性脑病会降低大鼠星形胶质细胞中钾离子诱发的钙摄取，但不会降低大鼠突触体中的钙摄取。

Acute hepatic encephalopathy decreases potassium-evoked calcium uptake in astrocytes but not in synaptosomes of the rat.

作者信息

Albrecht J, Lazarewicz J W

机构信息

Department of Neuropathology, Polish Academy of Sciences, Warsaw.

出版信息

Neurosci Lett. 1990 Apr 6;111(3):321-4. doi: 10.1016/0304-3940(90)90282-e.

DOI:10.1016/0304-3940(90)90282-e

PMID:2336207

Abstract

45CaCl2 uptake at low (5 mM), and high, depolarizing (65 mM) KCl concentration was measured in a fraction enriched in astrocytes, a crude mitochondrial-synaptosomal (P2) preparation and in purified synaptosomes derived from normal rats and from rats with thioacetamide-induced acute hepatic encephalopathy (HE). HE was found to reduce the potassium-evoked component of the astroglial uptake to 50% of its control level, without affecting the uptake into the P2 fraction or synaptosomes. The results are in keeping with the view that astrocytes are the cells whose metabolism and functions are predominantly affected during HE.

摘要

在低（5 mM）和高的去极化（65 mM）氯化钾浓度下，测定了富含星形胶质细胞的组分、粗制线粒体 - 突触体（P2）制剂以及从正常大鼠和硫代乙酰胺诱导的急性肝性脑病（HE）大鼠中分离出的纯化突触体对45CaCl2的摄取。发现HE可使星形胶质细胞摄取中钾诱导的成分降至对照水平的50%，而不影响P2组分或突触体的摄取。这些结果与以下观点一致，即星形胶质细胞是在HE期间其代谢和功能主要受到影响的细胞。