钯催化炔丙基碳酸酯与 4-羟基-2-吡喃酮环化反应区域控制构建呋喃[3,2-c]吡喃-4-酮衍生物。

Regiocontrolled construction of furo[3,2-c]pyran-4-one derivatives by palladium-catalyzed cyclization of propargylic carbonates with 4-hydroxy-2-pyrones.

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan.

出版信息

J Org Chem. 2013 Feb 15;78(4):1687-92. doi: 10.1021/jo3027092. Epub 2013 Feb 6.

Abstract

The reaction of propargylic carbonates with 4-hydroxy-2-pyrones in the presence of a palladium catalyst is described. By the choice of the reaction temperature, two types of the substituted furo[3,2-c]pyran-4-one derivatives were regioselectively synthesized, respectively.

摘要

描述了在钯催化剂存在下丙炔碳酸酯与 4-羟基-2-吡喃酮的反应。通过选择反应温度，可以分别选择性合成两种取代的呋喃[3,2-c]吡喃-4-酮衍生物。