Department of Psychiatry, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Sleep. 2013 Feb 1;36(2):197-202. doi: 10.5665/sleep.2372.
To investigate and elucidate the role of GABA(A) receptor subunits, specifically the 2 genetic markers at the GABA(A) α1 and GABA(A) α6 receptors, in zolpidem-induced complex sleep behaviors (CSBs).
Genetic association study.
Kaohsiung Medical University-affiliated hospitals, Kaohsiung, Taiwan.
30 zolpidem-induced CSB subjects and 37 controls.
N/A.
The χ(2) test demonstrated an association between the A15G variant at the GABA(A) α1 receptor subunit gene and zolpidem-induced CSBs (P = 0.007). The adjusted odds ratio of the GABA(A) α1 receptor subunit genotype for the risk of zolpidem-induced CSBs was approximately 10 (OR = 9.99, 95% CI = 1.82, 74.87; P = 0.013).
The finding reveals that the A15G variant at the GABA(A) α1 receptor subunit gene confers a high risk of zolpidem-induced CSBs and may be considered in clinical services.
调查和阐明 GABA(A) 受体亚基的作用,特别是 GABA(A)α1 和 GABA(A)α6 受体的 2 个遗传标记,在唑吡坦诱导的复杂睡眠行为(CSBs)中的作用。
遗传关联研究。
中国台湾高雄医科大学附属医院。
30 名唑吡坦诱导 CSB 患者和 37 名对照。
无。
卡方检验显示 GABA(A)α1 受体亚基基因 A15G 变异与唑吡坦诱导 CSBs 之间存在关联(P = 0.007)。GABA(A)α1 受体亚基基因型对唑吡坦诱导 CSBs 的风险的调整优势比约为 10(OR = 9.99,95%CI = 1.82,74.87;P = 0.013)。
该发现表明 GABA(A)α1 受体亚基基因的 A15G 变异赋予唑吡坦诱导 CSBs 的高风险,在临床服务中可以考虑。