• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一名儿童出现多个神经管缺陷：一种罕见的发育异常。

Multiple neural tube defects in a child: A rare developmental anomaly.

作者信息

Singh Neha, Singh Deepak Kumar, Aga Pallavi, Singh Ragini

机构信息

Department of Radiodiagnosis, Chhatrapati Sahuji Maharaj Medical University (CSMMU), Lucknow, Uttar Pradesh, India.

出版信息

Surg Neurol Int. 2012;3:147. doi: 10.4103/2152-7806.104741. Epub 2012 Dec 14.

DOI:10.4103/2152-7806.104741
PMID:23372964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3551503/
Abstract

BACKGROUND

The presence of multiple neural tube defects (NTDs) is a rare entity. Published literature shows not more than 10 case reports. Such cases contradict the well-established "zipper model" of neural tube closure and support "multi-site closure model."

CASE DESCRIPTION

We are reporting a unique case of multiple NTDs in a 5-month-o ld female child. Occipital encephalocele, dorsal meningomyelocele, Split cord malformation (SCM), and tethered cord were present in this case.

CONCLUSION

This case report further substantiate the "multisite closure model," however, more research work on human neuro-embryology is needed to overcome the controversies of neural tube closure.

摘要

背景

多发性神经管缺陷（NTDs）的存在是一种罕见情况。已发表的文献显示病例报告不超过10例。此类病例与公认的神经管闭合“拉链模型”相矛盾，并支持“多部位闭合模型”。

病例描述

我们报告了一名5个月大女童患有多发性NTDs的独特病例。该病例存在枕部脑膨出、背部脊膜脊髓膨出、脊髓纵裂畸形（SCM）和脊髓栓系。

结论

本病例报告进一步证实了“多部位闭合模型”，然而，需要更多关于人类神经胚胎学的研究工作来克服神经管闭合的争议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/066c/3551503/f8d042e29c5a/SNI-3-147-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/066c/3551503/fbab3b23909f/SNI-3-147-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/066c/3551503/6186b13bdad3/SNI-3-147-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/066c/3551503/3d9bf4c36526/SNI-3-147-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/066c/3551503/f8d042e29c5a/SNI-3-147-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/066c/3551503/fbab3b23909f/SNI-3-147-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/066c/3551503/6186b13bdad3/SNI-3-147-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/066c/3551503/3d9bf4c36526/SNI-3-147-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/066c/3551503/f8d042e29c5a/SNI-3-147-g004.jpg

相似文献

1
Multiple neural tube defects in a child: A rare developmental anomaly.一名儿童出现多个神经管缺陷：一种罕见的发育异常。
Surg Neurol Int. 2012;3:147. doi: 10.4103/2152-7806.104741. Epub 2012 Dec 14.
2
Triple neural tube defect and the multisite closure theory for neural tube defects: is there an additional site? Case report.神经管缺陷三联征与神经管缺陷的多部位闭合理论：是否存在额外的部位？病例报告。
J Neurosurg Pediatr. 2008 Feb;1(2):160-3. doi: 10.3171/PED/2008/1/2/160.
3
A case report of triple neural tube defect: revisiting the multisite closure theory.一例三重神经管缺陷病例报告：重新审视多部位闭合理论。
BMC Surg. 2019 Nov 6;19(1):164. doi: 10.1186/s12893-019-0633-2.
4
Triple neural tube defect--cranium bifidum with rostral and caudal spina bifida--live evidence of multi-site closure of the neural tube in humans.三重神经管缺陷——颅裂合并颅前和颅尾脊柱裂——人类神经管多部位闭合的现存证据。
Childs Nerv Syst. 2005 Apr;21(4):331-5. doi: 10.1007/s00381-004-1027-y. Epub 2004 Sep 29.
5
Evidence for multi-site closure of the neural tube in humans.人类神经管多部位闭合的证据。
Am J Med Genet. 1993 Oct 1;47(5):723-43. doi: 10.1002/ajmg.1320470528.
6
Neural tube defects at separate sites: further evidence in support of multi-site closure of the neural tube in humans.神经管在不同部位的缺陷：支持人类神经管多部位闭合的进一步证据。
Surg Neurol. 2009 Mar;71(3):353-6. doi: 10.1016/j.surneu.2007.08.030. Epub 2008 Feb 6.
7
Multiple-site neural tube defects: embryogenesis with complete review of existing literature.多部位神经管缺陷：胚胎发生及现有文献全面复习。
Neurosurg Focus. 2019 Oct 1;47(4):E18. doi: 10.3171/2019.8.FOCUS19437.
8
Multisite neural tube closure in humans.人类神经管的多部位闭合
Birth Defects Orig Artic Ser. 1996;30(1):203-25.
9
Concepts in the neurosurgical care of patients with spinal neural tube defects: An embryologic approach.脊髓神经管缺陷患者神经外科护理理念：胚胎学方法。
Birth Defects Res. 2019 Nov 15;111(19):1564-1576. doi: 10.1002/bdr2.1588. Epub 2019 Oct 2.
10
Multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation.多发性神经管缺陷：一种罕见的发育异常，其胚胎学解释尚不明确。
BJR Case Rep. 2023 Jul 10;9(6):20230005. doi: 10.1259/bjrcr.20230005. eCollection 2023 Nov.

引用本文的文献

1
Multiple neural tube defects: rare developmental anomaly with an elusive embryological explanation.多发性神经管缺陷：一种罕见的发育异常，其胚胎学解释尚不明确。
BJR Case Rep. 2023 Jul 10;9(6):20230005. doi: 10.1259/bjrcr.20230005. eCollection 2023 Nov.
2
Multiple-site neural tube defects complicated by multiple-site split cord malformations and thickened filum terminale: experience at a pediatric neurosurgical teaching hospital in Ethiopia. Illustrative case.多部位神经管缺陷合并多部位脊髓纵裂畸形和终丝增厚：埃塞俄比亚一家儿科神经外科教学医院的经验。病例说明。
J Neurosurg Case Lessons. 2022 Sep 19;4(12). doi: 10.3171/CASE22220.
3

本文引用的文献

1
Multiple neural tube defects: a clinical series of seven cases and their embryological basis.多发性神经管缺陷：7例临床病例系列及其胚胎学基础
Pediatr Neurosurg. 2008;44(4):280-7. doi: 10.1159/000131676. Epub 2008 May 15.
2
MULTIPLE PARAVERTEBRAL LUMBAR MENINGOCELE.
Br J Radiol. 1963 Aug;36:574-7. doi: 10.1259/0007-1285-36-428-574.
3
Evidence for multi-site closure of the neural tube in humans.人类神经管多部位闭合的证据。
Am J Med Genet. 1993 Oct 1;47(5):723-43. doi: 10.1002/ajmg.1320470528.
Multiple neural tube defects: a rare combination of limited dorsal myeloschisis, diplomyelia with dorsal bony spur, sacral meningocoele, syringohydromyelia, and tethered cord.
多发性神经管缺陷：一种罕见的组合，包括局限性脊髓背侧裂、伴有背侧骨棘的脊髓纵裂、骶部脊膜膨出、脊髓空洞症和脊髓栓系。
Childs Nerv Syst. 2017 Apr;33(4):699-701. doi: 10.1007/s00381-016-3310-0. Epub 2016 Dec 9.
4
Multiple neural tube defect with split cord malformation - a rare entity.合并脊髓纵裂畸形的多发性神经管缺陷——一种罕见病症。
Indian J Pediatr. 2014 Sep;81(9):982-3. doi: 10.1007/s12098-014-1383-x. Epub 2014 Mar 18.
4
Double myelomeningocele. A case report.
Turk J Pediatr. 1968 Jul;10(2):88-90.
5
The development of the human brain, the closure of the caudal neuropore, and the beginning of secondary neurulation at stage 12.在第12阶段人类大脑的发育、尾侧神经孔的闭合以及次级神经胚形成的开始。
Anat Embryol (Berl). 1987;176(4):413-30. doi: 10.1007/BF00310083.
6
Neural tube defects.神经管缺陷
JAMA. 1988;259(4):558-62.