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一名儿童出现多个神经管缺陷:一种罕见的发育异常。

Multiple neural tube defects in a child: A rare developmental anomaly.

作者信息

Singh Neha, Singh Deepak Kumar, Aga Pallavi, Singh Ragini

机构信息

Department of Radiodiagnosis, Chhatrapati Sahuji Maharaj Medical University (CSMMU), Lucknow, Uttar Pradesh, India.

出版信息

Surg Neurol Int. 2012;3:147. doi: 10.4103/2152-7806.104741. Epub 2012 Dec 14.

Abstract

BACKGROUND

The presence of multiple neural tube defects (NTDs) is a rare entity. Published literature shows not more than 10 case reports. Such cases contradict the well-established "zipper model" of neural tube closure and support "multi-site closure model."

CASE DESCRIPTION

We are reporting a unique case of multiple NTDs in a 5-month-o ld female child. Occipital encephalocele, dorsal meningomyelocele, Split cord malformation (SCM), and tethered cord were present in this case.

CONCLUSION

This case report further substantiate the "multisite closure model," however, more research work on human neuro-embryology is needed to overcome the controversies of neural tube closure.

摘要

背景

多发性神经管缺陷(NTDs)的存在是一种罕见情况。已发表的文献显示病例报告不超过10例。此类病例与公认的神经管闭合“拉链模型”相矛盾,并支持“多部位闭合模型”。

病例描述

我们报告了一名5个月大女童患有多发性NTDs的独特病例。该病例存在枕部脑膨出、背部脊膜脊髓膨出、脊髓纵裂畸形(SCM)和脊髓栓系。

结论

本病例报告进一步证实了“多部位闭合模型”,然而,需要更多关于人类神经胚胎学的研究工作来克服神经管闭合的争议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/066c/3551503/fbab3b23909f/SNI-3-147-g001.jpg

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