Department of Ophthalmology, Ministry of Health, Ankara Training and Research Hospital, Cebeci, Ankara, Turkey.
Curr Eye Res. 2013 Apr;38(4):480-6. doi: 10.3109/02713683.2013.763986. Epub 2013 Feb 1.
To determine and compare the incidence of intraoperative floppy iris syndrome (IFIS) features in patients using tamsulosin, and other chronic medications.
We prospectively studied patients who underwent phacoemulsification (PE) between March 2006 and October 2007 on use of tamsulosin or a single medication like antihypertansive (AH), antiaggregant (AAg), antipsycotic (AP) or oral antidiabetic (OAD). Patients were grouped as tamsulosin users (Group 1), previous tamsulosin users (Group 2), chronic medication users (AH, AAg, AP or OAD) (Group 3) and patients with no medication (Group 4). Comparison of pre and postoperative visual acuities, intraocular pressures, intraoperative posterior capsular rupture (PCR) rates and grades of IFIS among groups were evaluated.
We studied 1567 eyes of 1530 subjects. Twenty five eyes in the study demonstrated IFIS (1.6%). Five cases were included in Group 1 and IFIS incidence was 80%, while it was 60% in Group 2 (n = 5), 1 % in Group 3 (n = 1099), 1.7% in Group 4 (n = 421). IFIS incidence was significantly higher in Groups 1 and 2 compared to Groups 3 and 4 (p < 0.001). There was no difference between Groups 1 and 2 (p = 1.0) and between 3 and 4 (p = 0.29). Most cases (72%) had all three signs of IFIS. Complete IFIS was seen in one patient in Groups 1 and 2, whereas it was seen in all IFIS patients of Groups 3 and 4 (p < 0.001). Incidence of PCR was significantly higher in Group 1 (p = 0.045).
Tamsulosin was found to be the drug which was most likely to be associated with IFIS, but IFIS was also observed in patients chronically using losartan, aspirin, chlorpromazine and metformin. Although, IFIS incidences were found to be similar between chronic users of these drugs and those using no medications at the time of surgery, new studies in the future will introduce the predisposing factors and the possible mechanisms of IFIS with these medications.
确定和比较使用坦索罗辛和其他慢性药物的患者术中虹膜炎（IFIS）特征的发生率。
我们前瞻性研究了 2006 年 3 月至 2007 年 10 月期间接受白内障超声乳化术（PE）的患者，这些患者使用坦索罗辛或单一药物，如抗高血压药（AH）、抗血小板药（AAg）、抗精神病药（AP）或口服降糖药（OAD）。患者分为坦索罗辛使用者（第 1 组）、以前使用坦索罗辛的患者（第 2 组）、慢性药物使用者（AH、AAg、AP 或 OAD）（第 3 组）和未使用药物的患者（第 4 组）。评估各组之间术前和术后视力、眼内压、术中后囊破裂（PCR）率和 IFIS 分级的比较。
我们研究了 1530 名患者的 1567 只眼。研究中有 25 只眼出现 IFIS（1.6%）。第 1 组中有 5 例，IFIS 发生率为 80%，第 2 组为 60%（n=5），第 3 组为 1%（n=1099），第 4 组为 1.7%（n=421）。与第 3 组和第 4 组相比，第 1 组和第 2 组的 IFIS 发生率明显更高（p<0.001）。第 1 组和第 2 组之间无差异（p=1.0），第 3 组和第 4 组之间也无差异（p=0.29）。大多数病例（72%）有 IFIS 的所有三个体征。第 1 组和第 2 组各有 1 例完全 IFIS，而第 3 组和第 4 组所有 IFIS 患者均有（p<0.001）。第 1 组 PCR 发生率明显更高（p=0.045）。
坦索罗辛被发现是最有可能与 IFIS 相关的药物，但在慢性使用氯沙坦、阿司匹林、氯丙嗪和二甲双胍的患者中也观察到 IFIS。尽管在这些药物的慢性使用者和手术时未使用药物的患者之间发现 IFIS 发生率相似，但未来的新研究将介绍这些药物的易患因素和可能的 IFIS 机制。
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