Pinelli P
Muscle Nerve. 1978 Sep-Oct;1(5):438-41. doi: 10.1002/mus.880010521.
In most patients with myasthenia gravis, the mean duration and amplitude of motor unit potentials sampled in the extensor digitorum communis muscle, as well as the amplitude of the pattern of activity during full effort, increased after application of anticholinesterase. This appears to be a sensitive test for early detection of failure in neuromuscular transmission. In a series of 12 patients, the mean amplitude of motor unit potentials increased 30%-130% in 9, and the mean duration increased 10%-25% in 7. In 3 patients who failed to show an increase in amplitude in the extensor digitorum communis muscle, the amplitude of motor unit potentials increased in a facial or extraocular muscle after intravenous application of edrophonium. This increase in the amplitude or duration of motor unit potentials was even evident in 4 patients who failed to show a decrement in response of the opponens pollicis muscle to repetitive stimuli delivered to the median nerve at 3/sec and 5/sec. In 5 patients, responses evoked by stimuli delivered at 15/sec showed marked facilitation.
在大多数重症肌无力患者中，应用抗胆碱酯酶药物后，在指总伸肌中采集的运动单位电位的平均时限和波幅，以及全力收缩时的活动模式波幅均增加。这似乎是早期检测神经肌肉传递功能衰竭的一项敏感检查。在一组12例患者中，9例运动单位电位的平均波幅增加了30% - 130%，7例平均时限增加了10% - 25%。在3例指总伸肌波幅未增加的患者中，静脉注射依酚氯铵后，面部或眼外肌的运动单位电位波幅增加。在4例拇对掌肌对正中神经以3次/秒和5次/秒重复刺激的反应未出现递减的患者中，运动单位电位的波幅或时限增加也很明显。在5例患者中，以15次/秒给予刺激所诱发的反应显示出明显的易化现象。
