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尼罗罗非鱼(Oreochromis niloticus)胚胎发育过程中前部Hox基因的时空表达模式

Spatio-temporal expression patterns of anterior Hox genes during Nile tilapia (Oreochromis niloticus) embryonic development.

作者信息

Lyon R Stewart, Davis Adam, Scemama Jean-Luc

机构信息

Department of Biology, Howell Science Complex, East Carolina University, Greenville, NC 27858, USA.

出版信息

Gene Expr Patterns. 2013 Mar-Apr;13(3-4):104-8. doi: 10.1016/j.gep.2013.01.004. Epub 2013 Feb 1.

Abstract

Hox genes encode transcription factors that function to pattern regional tissue identities along the anterior-posterior axis during animal embryonic development. Divergent nested Hox gene expression patterns within the posterior pharyngeal arches may play an important role in patterning morphological variation in the pharyngeal jaw apparatus (PJA) between evolutionarily divergent teleost fishes. Recent gene expression studies have shown the expression patterns from all Hox paralog group (PG) 2-6 genes in the posterior pharyngeal arches (PAs) for the Japanese medaka (Oryzias latipes) and from most genes of these PGs for the Nile tilapia (Oreochromis niloticus). While several orthologous Hox genes exhibit divergent spatial and temporal expression patterns between these two teleost species in the posterior PAs, several tilapia Hox gene expression patterns from PG3-6 must be documented for a full comparative study. Here we present the spatio-temporal expression patterns of hoxb3b, c3a, b4a, a5a, b5a, b5b, b6a and b6b in the neural tube and posterior PAs of the Nile tilapia. We show that several of these tilapia Hox genes exhibit divergent expression patterns in the posterior PAs from their medaka orthologs. We also compare these gene expression patterns to orthologs in other gnathostome vertebrates, including the dogfish shark.

摘要

Hox基因编码转录因子,这些转录因子在动物胚胎发育过程中沿前后轴确定区域组织特征。咽后弓内不同的嵌套Hox基因表达模式可能在进化上不同的硬骨鱼之间的咽颌器官(PJA)形态变异形成中发挥重要作用。最近的基因表达研究显示了日本青鳉(Oryzias latipes)咽后弓(PAs)中所有Hox旁系同源基因组(PG)2 - 6基因的表达模式,以及尼罗罗非鱼(Oreochromis niloticus)这些PG中大多数基因的表达模式。虽然在这两种硬骨鱼的咽后弓中,几个直系同源Hox基因表现出不同的时空表达模式,但为了进行全面的比较研究,仍必须记录罗非鱼PG3 - 6的几个Hox基因表达模式。在这里我们展示了尼罗罗非鱼神经管和咽后弓中hoxb3b、c3a、b4a、a5a、b5a、b5b、b6a和b6b的时空表达模式。我们表明,这些罗非鱼Hox基因中的几个在咽后弓中的表达模式与其青鳉直系同源基因不同。我们还将这些基因表达模式与其他有颌脊椎动物(包括角鲨)的直系同源基因进行了比较。

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