一些 S-巯基三唑并苯并噻唑基氨基酸衍生物的合成及抑菌活性。
Synthesis and antifungal activity of some s-mercaptotriazolobenzothiazolyl amino acid derivatives.
机构信息
Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia 41511, Egypt.
出版信息
Eur J Med Chem. 2013 Feb;60:503-11. doi: 10.1016/j.ejmech.2012.10.033. Epub 2012 Oct 26.
A series of s-triazolobenzothiazolylthioacetyl/propionyl amino acid derivatives were synthesized with the aim of evaluating their antifungal activity. Their chemical structures were confirmed by (1)H, (13)C NMR, IR, mass spectrometry and elemental analyses. The synthesized derivatives were screened for their antifungal activity against Aspergillus flavus and Candida albicans. Five compounds (3, 5, 7c, 8 and 17) were found to possess high activity comparable to fluconazole at 100 μg/mL against C. albicans.
我们合成了一系列的 s-三唑并苯并噻唑基硫代乙酰基/丙酰基氨基酸衍生物，旨在评估它们的抗真菌活性。它们的化学结构通过 (1)H、(13)C NMR、IR、质谱和元素分析得到了确认。我们对合成的衍生物进行了抗黄曲霉和白色念珠菌的抗真菌活性筛选。在 100μg/mL 浓度下，有 5 种化合物（3、5、7c、8 和 17）对白色念珠菌表现出与氟康唑相当的高活性。
Zotero 插件