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Genetic evidence that the gene controlling Aub is located on chromosome 19.

作者信息

Zelinski T, Kaita H, Johnson K, Moulds M

机构信息

Department of Pediatrics, University of Manitoba, Canada.

出版信息

Vox Sang. 1990;58(2):126-8. doi: 10.1111/j.1423-0410.1990.tb02075.x.

Abstract

DNA from a series of families segregating for Aub was analyzed with a genomic DNA probe which defines a Bg1 I polymorphism for apolipoprotein C II (APOC2). The investigation revealed that the gene for Aub is closely linked to APOC2 (z = 8.43 at theta = 0.00) for paternal and maternal meioses combined, to LW (z = 3.61 at theta = 0.00) in paternal meioses and less closely linked to SE (z = 3.10 at theta = 0.09) for combined paternal and maternal meioses. Therefore, we propose a chromosome 19 location for the Aub gene.

摘要

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