外周肺病变的对比增强超声检查（CEUS）：60例研究
Contrast enhanced ultrasonography (CEUS) in peripheral lung lesions: A study of 60 cases.
作者信息
Caremani M, Benci A, Lapini L, Tacconi D, Caremani A, Ciccotosto C, Magnolfi A L
机构信息
Division of Infectious Disease, San Donato Hospital, Arezzo, Italy.
出版信息
J Ultrasound. 2008 Sep;11(3):89-96. doi: 10.1016/j.jus.2008.05.008. Epub 2008 Aug 6.
INTRODUCTION
The authors report their experience in 60 patients with infectious and neoplastic peripheral pulmonary lesions studied by conventional radiology, B-Mode ultrasound (US) and computed tomography (CT). In view of the particular pulmonary vascularization (consisting of both pulmonary and bronchial arteries) the patients underwent also contrast enhanced ultrasound (CEUS) using a II-generation contrast agent, SonoVue (sulphur hexafluoride microbubbles surrounded by a phospholipid shell).
METHODS AND RESULTS
In this study, the sensitivity of CEUS reached 95% in the characterization of peripheral pulmonary lesions, which is similar to the sensitivity of CT (97%). The method used in this case-study was free of significant side effects.
DISCUSSION
This preliminary clinical experience seems to confirm the possibility of using SonoVue enhanced US to make a differential diagnosis between infectious and neoplastic lesions based on a qualitative and quantitative assessment, by evaluating the enhancement pattern (homogeneous or inhomogeneous), arrival time of the contrast agent in the lesion, the possibility to identify the pulmonary arteries and time of contrast agent elimination.
引言
作者报告了他们对60例患有感染性和肿瘤性周围肺部病变患者的研究经验，这些患者接受了传统放射学、B超（US）和计算机断层扫描（CT）检查。鉴于肺部特殊的血管供应（由肺动脉和支气管动脉组成），患者还使用第二代造影剂声诺维（SonoVue，由磷脂壳包裹的六氟化硫微泡）进行了超声造影（CEUS）检查。
方法与结果
在本研究中，CEUS对外周肺部病变特征的敏感性达到95%，与CT的敏感性（97%）相似。本病例研究中使用的方法无明显副作用。
讨论
这一初步临床经验似乎证实了使用声诺维增强超声基于定性和定量评估来鉴别感染性和肿瘤性病变的可能性，具体是通过评估增强模式（均匀或不均匀）、造影剂在病变中的到达时间、识别肺动脉的可能性以及造影剂消除时间。
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