Department of Ophthalmology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
Ophthalmology. 2013 Jun;120(6):1300-4. doi: 10.1016/j.ophtha.2012.11.022. Epub 2013 Feb 8.
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies.
Retrospective, interventional cohort study.
All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital.
Review and analysis of patient records.
Implant exposure, extrusion and migration, socket contracture, and formation of pyogenic granuloma.
Sixty consecutive patients undergoing primary enucleation with no adjuvant chemotherapy or radiation with follow-up of at least 12 months were included. Retinoblastoma was the diagnosis in 59 eyes (98.3%). Median follow-up was 3.6 years (range, 1.0-9.3 years). Two implant sizes were used: 20 mm in 47 patients (78.3%) and 18 mm in 13 patients (21.7%). Overall, 52 patients (86.7%) had an event-free recovery. Polymer-coated hydroxyapatite implants (43/60, 71.7%), when compared with wrapped ones (17/60, 28.3%), had a trend toward greater event-free recovery (odds ratio [OR], 1.6; 95% confidence interval [CI], 0.3-7.7) and lower exposure rate (OR, 2.1; 95% CI, 0.4-10.5).
The use of polymer-coated hydroxyapatite implants is associated with favorable outcomes in the pediatric population. Despite observed complications, long-term implant retention is possible in most children.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
比较包裹和聚合物涂层羟磷灰石植入物在未接受辅助治疗的儿童初次眼内容剜除术中的应用。
回顾性、干预性队列研究。
1999 年至 2009 年期间在一家三级儿科癌症医院接受初次眼内容剜除术且未接受辅助治疗的所有儿童。
回顾和分析患者记录。
植入物暴露、脱出和迁移、眼窝缩窄和化脓性肉芽肿形成。
共纳入 60 例连续接受初次眼内容剜除术且未接受辅助化疗或放疗的患者（60 只眼），随访时间至少 12 个月。诊断为视网膜母细胞瘤的有 59 只眼（98.3%）。中位随访时间为 3.6 年（范围，1.0-9.3 年）。使用了两种植入物尺寸：20mm 大小的有 47 例（78.3%），18mm 大小的有 13 例（21.7%）。总体而言，52 例（86.7%）患者无事件恢复。与包裹的羟磷灰石植入物（17/60，28.3%）相比，聚合物涂层羟磷灰石植入物（43/60，71.7%）有更高的无事件恢复率（比值比[OR]，1.6；95%置信区间[CI]，0.3-7.7）和更低的暴露率（OR，2.1；95%CI，0.4-10.5）。
在儿科人群中，使用聚合物涂层羟磷灰石植入物可获得较好的结果。尽管观察到了并发症，但大多数儿童仍可长期保留植入物。
作者（们）对本文讨论的任何材料均无专有或商业利益。
