Department of Pathophysiology, University of Medicine and Pharmacy Grigore T. Popa, Universităţii Street, No. 16, 700115 Iaşi, Romania.
Mediators Inflamm. 2013;2013:169420. doi: 10.1155/2013/169420. Epub 2013 Jan 21.
Diabetes mellitus (DM) is a complex disease characterized by chronic hyperglycemia, a known risk factor for accelerated atherosclerosis and vascular disease. The aim of this study was to show that the connection between DM and other risk factors, such as dyslipidemia, inflammatory phenomena, or the development of certain vascular injuries, leads to a high frequency of thrombotic events in diabetic patients compared to the nondiabetic population. The study included one hundred eighty patients divided in the following groups: diabetic without ischemic cardiopathy-related disorders (DM), diabetic with clinical or off-clinical (electrocardiogram, cardiac ultrasound) ischemic cardiopathy-related disorders (DM + IC), and nondiabetic with ischemic cardiopathy-related disorders (IC). We investigated the following parameters: von Willebrand Factor, HDL-cholesterol, LDL-cholesterol, interleukin-1-beta, protein C, and plasminogen activator inhibitor type 1. The results achieved in our study have revealed the highest thrombotic risk among the groups of diabetic patients, which is in direct correlation with the high values of interleukin-1-beta and the modifications of lipid parameters, acknowledging the data in the literature, according to which hyperglycemia alters endothelial functions directly and indirectly by synthesis of growth factors and cytokines and generates metabolic disorders which would explain the high risk for thrombotic events.
糖尿病（DM）是一种复杂的疾病，其特征为慢性高血糖，已知这是加速动脉粥样硬化和血管疾病的风险因素。本研究旨在表明，DM 与其他风险因素（如血脂异常、炎症现象或某些血管损伤的发展）之间的联系，导致与非糖尿病患者相比，糖尿病患者发生血栓事件的频率更高。该研究纳入了 180 名患者，分为以下几组：无缺血性心脏病相关疾病的糖尿病患者（DM）、有临床或非临床（心电图、心脏超声）缺血性心脏病相关疾病的糖尿病患者（DM + IC）和有缺血性心脏病相关疾病的非糖尿病患者（IC）。我们研究了以下参数：血管性血友病因子、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、白细胞介素-1-β、蛋白 C 和纤溶酶原激活物抑制剂 1。我们的研究结果表明，糖尿病患者的血栓形成风险最高，这与白细胞介素-1-β和脂质参数的变化直接相关，证实了文献中的数据，根据这些数据，高血糖通过生长因子和细胞因子的合成直接和间接改变内皮功能，并产生代谢紊乱，这可以解释血栓形成事件的高风险。
