Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA.
Magn Reson Med. 2014 Jan;71(1):333-8. doi: 10.1002/mrm.24665. Epub 2013 Feb 14.
The purpose of this study was to determine if magnetization transfer contrast (MTC) imaging could be used to detect early macromolecular accumulation in a mouse model of early Alzheimer's disease.
We obtained MTC images at 9.4 T at three different age points in the Tg2576 mouse model of Alzheimer's disease. The Tg2576 mouse exhibits increased amyloid beta deposition that eventually progresses into amyloid beta plaque formation, increased hyper-phosphorylated tau but does not exhibit neurodegeneration.
Our results show an increase in the MTC signal that predates plaque formation and reported learning and memory deficits in the Tg2576 mouse. This increase in the MTC signal was reversed in a model of antioxidant therapy.
MTC magnetic resonance imaging can be used to detect early macromolecular changes in the Tg2576 mouse model of Alzheimer's disease. The source of the MTC contrast is likely complex and warrants further investigation in additional preclinical models that represent early and late stage Alzheimer's disease pathologies.
本研究旨在确定磁化转移对比（MTC）成像是否可用于检测早发性阿尔茨海默病小鼠模型中的早期大分子积累。
我们在阿尔茨海默病 Tg2576 小鼠模型的三个不同年龄点，在 9.4T 下获得 MTC 图像。Tg2576 小鼠表现出增加的淀粉样β沉积，最终进展为淀粉样β斑块形成，增加的过度磷酸化 tau 但不表现出神经退行性变。
我们的结果表明，在 Tg2576 小鼠中出现了 MTC 信号的增加，这早于斑块形成和报道的学习和记忆缺陷。这种 MTC 信号的增加在抗氧化治疗模型中得到了逆转。
MTC 磁共振成像可用于检测阿尔茨海默病 Tg2576 小鼠模型中的早期大分子变化。MTC 对比的来源可能很复杂，需要在代表早晚期阿尔茨海默病病理的其他临床前模型中进一步研究。
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