McKay Rebecca Jayne, Gilbert Lynne
Department of Reproductive Medicine, Cambridge Universities Hospitals NHS Foundation Trust, Cambridge, UK.
J Fam Plann Reprod Health Care. 2013 Jul;39(3):201-6. doi: 10.1136/jfprhc-2012-100495. Epub 2013 Feb 21.
When ulipristal acetate (UPA) was introduced into the Contraceptive and Sexual Health Services service in June 2011 an algorithm was developed to guide method selection. The aim was to encourage clinicians to assess risk and to offer a copper intrauterine device (IUD) as first-line choice with hormonal methods as second-line choice.
UPA was the second-line choice for presentations up to 120 hours after high-risk episodes (i.e. around the time of ovulation). Women at lower risk were also offered UPA if presentation was between 72 and 120 hours after unprotected intercourse unless the risk was very low, in which case levonorgestrel 1.5 mg was the second-line choice.
Prior to the protocol only 49% of women were offered an IUD compared with 61.6% afterwards. This improved further in the subgroup of women at high risk where 93.3% were offered an IUD compared with 59% initially. After the introduction of UPA the percentage of women accepting the IUD fell from 30% to 14.1%. Overall 14.5% of women received UPA compared to 7.8% receiving an IUD.
Introduction of a standardised protocol for the provision of emergency contraception has significantly increased the proportion of women offered an IUD as postcoital contraception, particularly in women at high risk of conception. Introduction of UPA has seen a halving of the number of women accepting the IUD. This is cause for concern. Further investigation into the reasons behind this decrease in IUD uptake needs to be undertaken.
2011年6月醋酸乌利司他(UPA)引入避孕与性健康服务时,制定了一种算法来指导方法选择。目的是鼓励临床医生评估风险,并将铜宫内节育器(IUD)作为一线选择,激素方法作为二线选择。
对于高危事件发生后长达120小时(即排卵前后)前来就诊的患者,UPA是二线选择。低风险女性在无保护性交后72至120小时前来就诊时也可使用UPA,除非风险极低,在这种情况下,1.5毫克左炔诺孕酮是二线选择。
在该方案实施前,只有49%的女性使用了IUD,而之后这一比例为61.6%。在高危女性亚组中这一比例进一步提高,其中93.3%的女性使用了IUD,而最初这一比例为59%。引入UPA后,接受IUD的女性比例从30%降至14.1%。总体而言,14.5%的女性接受了UPA,而接受IUD的女性为7.8%。
引入标准化的紧急避孕方案显著提高了作为性交后避孕方法而使用IUD的女性比例,尤其是在受孕风险高的女性中。引入UPA后,接受IUD的女性数量减半。这令人担忧。需要对IUD使用减少背后的原因进行进一步调查。