动脉粥样硬化中的亲环素：新的治疗靶点？
Cyclophilins in atherosclerosis: a new therapeutic target?
机构信息
GWU SMHS, 2300 Eye St. NW, Ross Hall Rm. 736, Washington, DC 20037.
出版信息
Curr Pharm Des. 2013;19(33):5904-8. doi: 10.2174/1381612811319330009.
PMID:23438962
Abstract
Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible approaches to selectively target this novel proinflammatory factor.
摘要
动脉粥样硬化是一种慢性疾病，具有显著的炎症成分。最近的研究表明细胞外亲环素作为内皮炎症和动脉粥样硬化发病机制的贡献者的作用。在本文中，我们回顾了细胞外亲环素的促炎活性的现有文献，并讨论了针对这种新型促炎因子的可能方法。
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