Urology Department, Assistance Publique des Hôpitaux de Paris, Henri Mondor Teaching Hospital, Créteil, France.
J Sex Med. 2013 May;10(5):1355-62. doi: 10.1111/jsm.12109. Epub 2013 Feb 27.
The effects of intracavernous alprostadil injection (IAI), a primary treatment for post-radical prostatectomy (RP) erectile dysfunction (ED) (pRPED), on the sex life of women partnered with men who have undergone RP have received little attention.
The aim of this study is to investigate the sexual quality of life in female partners of men receiving IAIs for pRPED.
We retrospectively studied the sex lives of 152 women partnered with men who were being treated for pRPED with IAI and previously had normal erectile function. Women completed the Index of Sexual Life (ISL) questionnaire 1 year after their partner's RP. Male patients completed the International Index of Erectile Function (IIEF-15), the Erection Hardness Score (EHS) questionnaire, the International Consultation on Incontinence Questionnaire (ICIQ), and the UCLA Prostate Cancer Index (UCLA-PCI) urinary function questionnaire. Penile pain was assessed using the visual analog scale (VAS). Statistical analysis was performed using t-tests, Spearman correlation, and multiple linear regression.
Female sexual life satisfaction (SLS), sexual drive (SD), and general life satisfaction (GLS) were assessed using the ISL questionnaire.
Mean ages for the 104 couples included were 62.3 and 59.8 years for the men and women, respectively. Mean ISL, SD, SLS, and GLS scores at 12 months were 25.4, 3.8, 14.1, and 7.5, respectively. ISL scores were strongly correlated with IIEF-15 domains, mainly erectile function (r > 0.41, P < 0.00002) and intercourse satisfaction (r > 0.27, P < 0.005). Age and VAS, ICIQ, and UCLA-PCI scores were negatively correlated with some ISL domains. IIEF-15 erectile function and intercourse satisfaction were the most significant domains predicting female SLS. An IIEF-15 erectile function of 25 corresponded to a 75% chance of an SLS score ≥18.
Indexes of female sexual quality of life were low overall but were highly correlated with the partner's response level to IAI treatment. IAI-related pain, increased age, and poor urinary function of the male partner appear to negatively impact female sex life.
阴茎海绵体内注射前列地尔（IAI）是治疗根治性前列腺切除术后勃起功能障碍（ED）（pRPED）的主要方法，但其对接受过 RP 的男性伴侣的性生活质量的影响却很少受到关注。
本研究旨在探讨接受 pRPED 治疗的男性伴侣接受 IAI 治疗后女性伴侣的性生活质量。
我们回顾性研究了 152 名女性伴侣的性生活，这些女性伴侣的伴侣因 pRPED 接受 IAI 治疗，且之前勃起功能正常。女性伴侣在伴侣接受 RP 治疗 1 年后完成性生活指数（ISL）问卷。男性患者完成国际勃起功能指数（IIEF-15）、勃起硬度评分（EHS）问卷、国际尿失禁咨询问卷（ICIQ）和 UCLA 前列腺癌指数（UCLA-PCI）尿功能问卷。阴茎疼痛采用视觉模拟评分（VAS）进行评估。使用 t 检验、Spearman 相关分析和多元线性回归进行统计分析。
女性性生活满意度（SLS）、性驱动（SD）和一般生活满意度（GLS）使用 ISL 问卷进行评估。
104 对夫妇的平均年龄分别为男性 62.3 岁和女性 59.8 岁。12 个月时的平均 ISL、SD、SLS 和 GLS 评分分别为 25.4、3.8、14.1 和 7.5。ISL 评分与 IIEF-15 各领域高度相关，主要与勃起功能（r>0.41，P<0.00002）和性交满意度（r>0.27，P<0.005）相关。年龄和 VAS、ICIQ 和 UCLA-PCI 评分与部分 ISL 领域呈负相关。IIEF-15 勃起功能和性交满意度是预测女性 SLS 的最重要领域。IIEF-15 勃起功能得分为 25 分，女性 SLS 评分≥18 的可能性为 75%。
女性性生活质量指数总体较低，但与伴侣对 IAI 治疗的反应水平高度相关。IAI 相关疼痛、年龄增长和男性伴侣的尿功能不良似乎对女性性生活产生负面影响。
