Professor of Neurological Sciences, Neurosurgery, Internal Medicine, and Anesthesiology, Rush Medical College, Chicago, IL ; Associate Chief Medical Officer (Critical Care), Rush University Medical Center, Chicago, IL.
Epilepsy Curr. 2012 Nov;12(6):225-8. doi: 10.5698/1535-7511-12.6.225.
Seizures and stroke are both common neurologic conditions, but when they occur in close temporal proximity they produce much more concern than either does alone. The stroke specialist (and the family) fear that convulsions will worsen the stroke because of acute hypertension and airway compromise, and the epileptologist is concerned that these acute seizures are the harbingers of later epilepsy. Other less commonly recognized but important aspects of this relationship are that subclinical seizures worsen some forms of stroke, and some anticonvulsants may have more adverse effects on stroke patients than they do in other groups. In surveying the connections between these two conditions, I have attempted to address seven questions. For some questions, there are data to help provide an answer; for others, there is only opinion; and for a maddening few, newer research is making older suggestions less certain.
癫痫发作和中风都是常见的神经系统疾病,但当它们在时间上非常接近时,它们引起的关注比单独发生时要多得多。中风专家(和患者的家属)担心癫痫发作会因急性高血压和气道阻塞而使中风恶化,而癫痫专家则担心这些急性发作是日后发生癫痫的先兆。这种关系还有其他一些不太常见但很重要的方面,即亚临床癫痫发作会使某些类型的中风恶化,而一些抗癫痫药物对中风患者的影响可能比其他人群更大。在探讨这两种情况之间的联系时,我试图回答七个问题。对于一些问题,有数据可以帮助提供答案;对于其他问题,只有意见;而对于少数令人抓狂的问题,新的研究使旧的建议变得不那么确定。