锝-99m氨基酸螯合物：其物理化学和生理参数的相关性。第一部分。

Technetium-99m amino acid chelates: correlation of their physico-chemical and physiological parameters. Part I.

作者信息

Chakravarty M, Sanyal S, Banerjee S

机构信息

Department of Nuclear Medicine, Indian Institute of Chemical Biology, Calcutta.

出版信息

J Inorg Biochem. 1990 May;39(1):43-57. doi: 10.1016/0162-0134(90)80014-o.

DOI:10.1016/0162-0134(90)80014-o

PMID:2345372

Abstract

Ten alpha-aminocarboxylic acids were chelated with 99mTc and purified by sephadex gel chromatography. Their hepatobiliary and renal excretion patterns were determined in rats. It was observed that lipophilicity of these chelates is the only determinant in governing their hepatobiliary excretion, whereas their renal excretion is dependent on some other factors in addition to lipophilicity. Depression of renal excretion in presence of probenecid indicated an interaction of renal tubular transport enzymes with these chelates, which was explained from their hexacoordinated dioxotechnetium (V) chelate structure (II).

摘要

十种α-氨基羧酸与99mTc螯合，并通过葡聚糖凝胶色谱法进行纯化。在大鼠体内测定了它们的肝胆和肾脏排泄模式。观察到这些螯合物的亲脂性是决定其肝胆排泄的唯一因素，而它们的肾脏排泄除亲脂性外还取决于其他一些因素。丙磺舒存在时肾脏排泄的降低表明肾小管转运酶与这些螯合物之间存在相互作用，这可从它们的六配位二氧锝（V）螯合物结构（II）得到解释。