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一名肝移植受者出现具有移植物抗宿主病样特征的霉酚酸酯诱导的结肠炎。

Mycophenolate mofetil-induced colitis with graft versus host disease-like features in a liver transplant recipient.

作者信息

Patra Sushma, Vij Mukul, Sukanya B, Kapoor Dharmesh

机构信息

Department of Pathology, Global Hospitals and Health City, Chennai, Tamilnadu, India.

出版信息

Indian J Pathol Microbiol. 2012 Oct-Dec;55(4):506-8. doi: 10.4103/0377-4929.107792.

Abstract

Mycophenolate mofetil (MMF) is a commonly used immunosuppressive drug in the management of transplant recipients. Gastrointestinal (GI) toxicity (diarrhea) is the most frequently reported adverse event in MMF-treated transplant patients. MMF-induced Graft versus Host Disease has rarely been reported in literature. We report a case of MMF-induced colitis with Graft versus Host Disease-like features, to highlight the importance of high clinical suspicion for its diagnosis, and that appropriate management in such a setting can reduce morbidity and mortality. We also review the relevant literature.

摘要

霉酚酸酯(MMF)是移植受者管理中常用的免疫抑制药物。胃肠道(GI)毒性(腹泻)是接受MMF治疗的移植患者中最常报告的不良事件。MMF诱导的移植物抗宿主病在文献中很少有报道。我们报告一例具有移植物抗宿主病样特征的MMF诱导的结肠炎病例,以强调对此类疾病诊断保持高度临床怀疑的重要性,以及在此种情况下进行适当管理可降低发病率和死亡率。我们还回顾了相关文献。

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