Patra Sushma, Vij Mukul, Sukanya B, Kapoor Dharmesh
Department of Pathology, Global Hospitals and Health City, Chennai, Tamilnadu, India.
Indian J Pathol Microbiol. 2012 Oct-Dec;55(4):506-8. doi: 10.4103/0377-4929.107792.
Mycophenolate mofetil (MMF) is a commonly used immunosuppressive drug in the management of transplant recipients. Gastrointestinal (GI) toxicity (diarrhea) is the most frequently reported adverse event in MMF-treated transplant patients. MMF-induced Graft versus Host Disease has rarely been reported in literature. We report a case of MMF-induced colitis with Graft versus Host Disease-like features, to highlight the importance of high clinical suspicion for its diagnosis, and that appropriate management in such a setting can reduce morbidity and mortality. We also review the relevant literature.
霉酚酸酯(MMF)是移植受者管理中常用的免疫抑制药物。胃肠道(GI)毒性(腹泻)是接受MMF治疗的移植患者中最常报告的不良事件。MMF诱导的移植物抗宿主病在文献中很少有报道。我们报告一例具有移植物抗宿主病样特征的MMF诱导的结肠炎病例,以强调对此类疾病诊断保持高度临床怀疑的重要性,以及在此种情况下进行适当管理可降低发病率和死亡率。我们还回顾了相关文献。