[健康男性和女性血清骨钙素水平与年龄的关系]
[Serum osteocalcin levels in healthy males and females in relation to age].
作者信息
Lakatos P, Tarján G, Vargha P
机构信息
Semmelweis Orvostudományi Egyetem, I. sz. Belklinka, Budapest.
出版信息
Orv Hetil. 1990 Apr 22;131(16):853-7.
The measurement of serum osteocalcin is a new sensitive and specific method in the evaluation of calcium metabolism disorders. We established the normal values of healthy adult Hungarian women (n = 111, age: 20-86 yrs, mean: 47 yrs) and men (n = 70, age: 20-88 yrs, mean: 42 yrs) by radioimmunoassay method developed at our institute. Serum osteocalcin levels are constant between 20-50 yrs (7,8 +/- 2,4 ng/ml) while the values are significantly higher after 50 yrs of age (11,0 +/- 4,6 ng/ml) and remain constant afterwards. A correlation might be supposed between this elevation around 50 and bone loss around menopause. Serum osteocalcin values of men are constant with aging (11,0 +/- 3,9 ng/ml).
血清骨钙素的测定是评估钙代谢紊乱的一种新的敏感且特异的方法。我们通过本研究所研发的放射免疫分析法，确立了健康成年匈牙利女性（n = 111，年龄：20 - 86岁，平均：47岁）和男性（n = 70，年龄：20 - 88岁，平均：42岁）的正常值。血清骨钙素水平在20 - 50岁之间保持恒定（7.8 ± 2.4 ng/ml），而在50岁之后该值显著升高（11.0 ± 4.6 ng/ml），且此后保持稳定。可以推测50岁左右的这种升高与绝经前后的骨质流失之间可能存在关联。男性的血清骨钙素值随年龄增长保持稳定（11.0 ± 3.9 ng/ml）。
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