[阿片受体阻断对应激条件下抗体反应和增殖反应的影响]
[Effect of opioid receptor blockade on antibody response and proliferative response under stress conditions].
作者信息
Geĭn S V, Sharav'eva I L
出版信息
Eksp Klin Farmakol. 2013;76(1):30-4.
It is established that rotation and immobilization stress produces bidirectional effect on AFC number in spleen and on proliferative response of splenocytes. The rotation stress results in augmentation of AFC formation and promotion of spontaneous proliferative activity of splenocytes. The micro-opioid receptor blockade with naloxone, but not delta-receptor blockade with naltrindole, abolished the effects of rotation. In contrast, the immobilization stress caused the suppression of the parameters of humoral immune response and lowered spontaneous and induced proliferative activity of splenocytes. The opioid receptor blockade with naloxone was found to level the suppressive effects of immobilization, while naltrindole exhibited a less pronounced effect. Both variants of stress demonstrated the involvement of opioid system in regulation of AFC number during induction of the immune response.
现已确定，旋转和固定应激对脾脏中抗体形成细胞（AFC）数量以及脾细胞的增殖反应产生双向影响。旋转应激导致AFC形成增加并促进脾细胞的自发增殖活性。用纳洛酮进行微阿片受体阻断，但用纳曲吲哚进行δ受体阻断则不能消除旋转的影响。相反，固定应激导致体液免疫反应参数受到抑制，并降低脾细胞的自发和诱导增殖活性。发现用纳洛酮进行阿片受体阻断可消除固定的抑制作用，而纳曲吲哚的作用则不太明显。两种应激变体均表明阿片系统参与免疫反应诱导过程中AFC数量的调节。
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