Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Rhode Island Hospital, 593 Eddy St., Providence, RI 02903, USA.
J Vasc Interv Radiol. 2013 Apr;24(4):476-82. doi: 10.1016/j.jvir.2012.12.016. Epub 2013 Feb 23.
To retrospectively evaluate cost and mortality in 84 patients older than 65 years of age with stage IA or IB non-small-cell lung cancer treated with radiofrequency (RF) ablation or limited surgical resection (ie, wedge resection or segmentectomy) from the perspective of the payer, Medicare.
From August 2000 to November 2009, 56 patients were treated with RF ablation and 28 with surgery who met the inclusion criteria. Patient health histories and billing charges from initial treatment to the study endpoint were collected. Charges were converted to 2009 Medicare reimbursement fees and cumulated by month. Time-event data were analyzed by using the Kaplan-Meier method. Survival functions and median survival estimates were reported with standard errors. Patient cohorts' survival functions were compared based on the Wilcoxon weighted χ(2) statistic.
Group demographics were comparable with the exception of age, with patients treated with RF ablation an average of 4 years older (95% confidence interval, 0.85-6.76). The overall mortality rate was lower in patients treated with surgery than in those treated with RF ablation (χ(2) = 8.0225, P = .0046), with a median cost per month lived for RF ablation recipients of $620.74, versus $1,195.92 for those treated with surgery (P = .0002, Wilcoxon rank-sum test).
Patients treated with surgery showed a significant increase in survival; however, those treated with RF ablation were significantly older. For patients who are not surgical candidates, RF ablation provides an alternative treatment option at a significantly lower cost.
从支付方 Medicare 的角度回顾性评估 84 例年龄超过 65 岁的 IA 期或 IB 期非小细胞肺癌患者的治疗费用和死亡率,这些患者接受的治疗方法为射频 (RF) 消融或有限的手术切除(即楔形切除术或肺段切除术)。
2000 年 8 月至 2009 年 11 月,符合纳入标准的 56 例患者接受了 RF 消融治疗,28 例患者接受了手术治疗。收集患者的健康史和初始治疗至研究终点的计费费用。费用转换为 2009 年 Medicare 报销费用,并按月累计。采用 Kaplan-Meier 法分析时间事件数据。报告生存函数和中位生存估计值,并给出标准误差。根据 Wilcoxon 加权 χ(2)统计量比较两组患者的生存函数。
两组患者的人口统计学特征相当,但接受 RF 消融治疗的患者平均年龄大 4 岁(95%置信区间,0.85-6.76)。与接受 RF 消融治疗的患者相比,接受手术治疗的患者的总体死亡率较低(χ(2) = 8.0225,P =.0046),接受 RF 消融治疗的患者每月的生存费用中位数为 620.74 美元,而接受手术治疗的患者为 1195.92 美元(P =.0002,Wilcoxon 秩和检验)。
接受手术治疗的患者生存时间显著延长,但接受 RF 消融治疗的患者年龄明显更大。对于不符合手术条件的患者,RF 消融治疗是一种成本显著降低的替代治疗方法。