两例急性髓系白血病合并噬血细胞性淋巴组织细胞增生症及文献复习

Two acute myeloblastic leukemia cases concomitant with hemophagocytic lymphohistiocytosis and review of the literature.

作者信息

Akyay Arzu, Celkan Tiraje, Iskender Gülşen, Tükün Ajlan, Ogan Cihat, Olcay Lale

机构信息

Dr. A.Y. Ankara Oncology Training and Research Hospital, Division of Pediatric Hematology, Ankara, Turkey.

出版信息

Ann Clin Lab Sci. 2013 Winter;43(1):85-90.

PMID:23462611

Abstract

We present two patients with acute myeloblastic leukemia (FAB AML-M7 and AML-M2) complicated by hemophagocytic lymphohistiocytosis (HLH) and relevant literature review. To our knowledge, our first case is the first and youngest patient having AML-M7 associated with HLH reported in the literature. Our cases and cases in the literature highlight the high mortality rate of leukemia associated with HLH and the need for further investigation for the most appropriate therapy.

摘要

我们报告了两名急性髓系白血病患者（FAB AML-M7和AML-M2）并发噬血细胞性淋巴组织细胞增生症（HLH），并进行了相关文献综述。据我们所知，我们的首例病例是文献报道中首例也是最年轻的患有AML-M7合并HLH的患者。我们的病例以及文献中的病例凸显了白血病合并HLH的高死亡率，以及对最恰当治疗方法进行进一步研究的必要性。