Cardiology Service, IRCCS/CROB, Rionero in Vulture (PZ), Italy.
Clin Transl Oncol. 2013 Oct;15(10):861-4. doi: 10.1007/s12094-013-1023-3. Epub 2013 Mar 6.
To investigate the effect of external beam radiotherapy (EBRT) for head and neck cancer (HNC) the intimal-medial thickness (IMT) and the lumen of the carotid artery.
Patients with HNC and an indication for EBRT were enrolled. A carotid artery color Doppler examination was performed before and 6 and 12 months after EBRT.
From 2008 to 2011, 50 patients were enrolled. The mean carotid IMT was 0.9 vs. 1.02 mm before and 6 months after EBRT, respectively (p = 0.0001). The common carotid artery lumen was narrowed without statistical significance, 6 months after EBRT (p = 0.3). 1 year from EBRT, the IMT increase and the lumen reduction were statistically significant (p = 0.001, p = 0.01, respectively). Neurological events (stroke or TIA) were not observed.
Our data showed a significant IMT increase 6 months from EBRT without a corresponding narrowing of the common carotid lumen while a significant increase 12 months after EBRT.
研究头颈部癌症（HNC）患者接受外照射放疗（EBRT）后颈动脉内-中膜厚度（IMT）和管腔的变化。
纳入需要接受 EBRT 的 HNC 患者。在 EBRT 之前以及 6 个月和 12 个月后进行颈动脉彩色多普勒超声检查。
2008 年至 2011 年期间，共纳入 50 例患者。颈动脉 IMT 平均值分别为 0.9 毫米和 1.02 毫米（p = 0.0001）。EBRT 后 6 个月，颈总动脉管腔变窄，但无统计学意义（p = 0.3）。EBRT 后 1 年，IMT 增加和管腔减少具有统计学意义（p = 0.001，p = 0.01）。未观察到神经事件（中风或 TIA）。
我们的数据显示，EBRT 后 6 个月 IMT 显著增加，而颈总动脉管腔没有相应变窄，12 个月后则显著增加。
