El-Chaar Darine, Finkelstein Sara A, Tu Xiaowen, Fell Deshayne B, Gaudet Laura, Sylvain Jacques, Tawagi George, Wu Wen Shi, Walker Mark
Department of Obstetrics, Gynecology and Newborn Care, The Ottawa Hospital, Ottawa ON; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ottawa ON.
Obstetrics & Maternal Newborn Investigations (OMNI), The Ottawa Hospital, Ottawa ON.
J Obstet Gynaecol Can. 2013 Mar;35(3):224-233. doi: 10.1016/S1701-2163(15)30994-4.
Nationally, rates of obesity continue to rise, resulting in increased health concerns for women of reproductive age. Identifying the impact of maternal obesity on obstetrical outcomes is important to enhance patient care.
We conducted a retrospective cohort study of 6674 women who delivered a singleton infant at ≥ 20 weeks' gestation between December 1, 2007, and March 31, 2010, at The Ottawa Hospital. Maternal pre-pregnancy BMI was used to classify women into normal, overweight, and obese (class I/II/III) categories according to WHO classifications. Obstetrical outcomes among obese women were compared with those of women with normal BMI. Multivariable regression models were used to determine adjusted odds ratios and 95% confidence intervals.
Compared with women with normal BMI, obese women had significantly higher rates of preeclampsia, gestational hypertension, and gestational diabetes, and these rates increased with increasing BMI (trend-test P < 0.001). There was a significant increase in rates of induction of labour in the obesity categories, from 25.3% in women with normal BMI to 42.9% in women with class III morbid obesity (aOR 1.67; 95% CI 1.43 to 1.93). Rates of primary Caesarean section rose with increasing BMI and were highest in women with class III morbid obesity (36.2% vs. 22.1% in women with normal BMI) (aOR 1.46; 95% CI 1.23 to 1.73).
Increasing BMI is associated with increasing rates of preeclampsia, gestational hypertension, and gestational diabetes. There is a significant increase in rates of induction of labour with increasing obesity class, and a significantly increased Caesarean section rate with higher BMI. Obstetrical care providers should counsel obese patients about the risks they face and the importance of weight loss before pregnancy.
在全国范围内,肥胖率持续上升,这使得育龄妇女的健康问题日益受到关注。确定孕产妇肥胖对产科结局的影响对于提高患者护理水平至关重要。
我们对2007年12月1日至2010年3月31日期间在渥太华医院分娩单胎婴儿且孕周≥20周的6674名妇女进行了一项回顾性队列研究。根据世界卫生组织的分类,将孕前体重指数(BMI)用于将妇女分为正常、超重和肥胖(I/II/III级)类别。将肥胖妇女的产科结局与BMI正常的妇女进行比较。使用多变量回归模型来确定调整后的优势比和95%置信区间。
与BMI正常的妇女相比,肥胖妇女患先兆子痫、妊娠期高血压和妊娠期糖尿病的发生率显著更高,且这些发生率随着BMI的增加而上升(趋势检验P<0.001)。肥胖类别中引产率显著增加,从BMI正常的妇女中的25.3%增加到III级重度肥胖妇女中的42.9%(调整后的优势比为1.67;95%置信区间为1.43至1.93)。剖宫产率随着BMI的增加而上升,在III级重度肥胖妇女中最高(36.2%对比BMI正常的妇女中的22.1%)(调整后的优势比为1.46;95%置信区间为1.23至1.73)。
BMI的增加与先兆子痫、妊娠期高血压和妊娠期糖尿病的发生率增加相关。随着肥胖等级的增加,引产率显著增加,且BMI越高剖宫产率显著增加。产科护理人员应向肥胖患者咨询她们面临的风险以及孕前减肥的重要性。