良性前列腺增生中老年男性低睾酮症的流行率：来自保列治长期疗效和安全性研究（PLESS）的数据。

Prevalence of low testosterone in aging men with benign prostatic hyperplasia: data from the Proscar Long-term Efficacy and Safety Study (PLESS).

机构信息

Institute of Bladder and Prostate Health, Weill Cornell Medical College, New York, NY 10065, USA.

出版信息

Aging Male. 2013 Jun;16(2):48-51. doi: 10.3109/13685538.2013.773421. Epub 2013 Mar 12.

DOI:10.3109/13685538.2013.773421

PMID:23480623

Abstract

OBJECTIVES

We examined the prevalence of low testosterone (LT) in the subset of men in the Proscar Long-term Efficacy and Safety Study (PLESS) who had serum total testosterone (TT) measured at baseline.

METHODS

PLESS enrolled 3040 men with benign prostatic hyperplasia (BPH). Of these men, 299 had TT and body mass index (BMI) measurements at baseline. Patients were classified as having LT if their baseline TT was <300 ng/dl.

RESULTS

Of the 299 PLESS patients with baseline TT and BMI measurements, 65 (21.7%) had LT. The prevalence of LT increased with increasing BMI, occurring in 8/78 (10.3%) normal weight patients (baseline BMI <25 kg/m2), 35/160 (21.9%) overweight patients (baseline BMI ≥25-<30 kg/m2), and 22/61 (36.1%) obese patients (baseline BMI ≥30 kg/m2).

CONCLUSIONS

LT was observed in more than one in five PLESS patients with baseline TT and BMI measurements. The prevalence of LT increased with increasing BMI - more than one in three obese PLESS patients with baseline TT measurements had LT.

摘要

目的

我们检测了前列腺增生长期疗效和安全性研究（PLESS）中基线时检测到血清总睾酮（TT）的男性亚组中低睾酮（LT）的患病率。

方法

PLESS 纳入了 3040 名患有良性前列腺增生（BPH）的男性。其中 299 名男性基线时 TT 和体重指数（BMI）测量。如果基线 TT <300ng/dl，则将患者归类为 LT。

结果

在基线 TT 和 BMI 测量的 299 名 PLESS 患者中，有 65 名（21.7%）患有 LT。随着 BMI 的增加，LT 的患病率增加，8/78（10.3%）体重正常的患者（基线 BMI <25kg/m2）、35/160（21.9%）超重患者（基线 BMI≥25-<30kg/m2）和 22/61（36.1%）肥胖患者（基线 BMI≥30kg/m2）发生 LT。