School of Behavioral Sciences, The Academic College of Tel Aviv-Yaffo, Yaffo, Israel.
J Neuroimmunol. 2013 Apr 15;257(1-2):59-66. doi: 10.1016/j.jneuroim.2013.02.009. Epub 2013 Mar 13.
Neonatal stress increased the duration and augmented symptoms of sickness behavior induced by influenza virus infection or endotoxin challenge in mice. Since proinflammatory cytokines were implicated in sickness behavior, the present study sought to determine the effect of neonatal stress on cytokines-induced sickness behavior and on proinflammatory cytokine secretion. Data indicate that separation of mouse pups from the dams at an early age (maternal separation, MSP) increased the duration and augmented some of the symptoms of sickness behavior induced by proinflammatory cytokines. In addition, MSP partially suppressed cytokine and corticosterone secretion in response to endotoxin administration. These data may suggest that MSP increased sensitivity to the effects of proinflammatory cytokines on sickness behavior following an immune challenge.
新生儿应激增加了流感病毒感染或内毒素挑战诱导的小鼠疾病行为的持续时间和加重症状。由于促炎细胞因子与疾病行为有关，本研究旨在确定新生儿应激对细胞因子诱导的疾病行为和促炎细胞因子分泌的影响。数据表明，在早期将小鼠幼仔与母鼠分开（母体分离，MSP）会增加促炎细胞因子诱导的疾病行为的持续时间并加重其某些症状。此外，MSP 部分抑制了对内毒素给药的细胞因子和皮质酮的分泌。这些数据可能表明，MSP 增加了对免疫挑战后促炎细胞因子对疾病行为影响的敏感性。
