Takaki Manabu, Ujike Hiroshi
Department of Neuropsychiatry Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan.
Clin Neuropharmacol. 2013 Mar-Apr;36(2):68-9. doi: 10.1097/WNF.0b013e318280028a.
Blonanserin (BNS) is used for treatment of both positive and negative symptoms of schizophrenia in Japan and Korea. Because BNS has weak α1 receptor blocking activities and is almost devoid of histamine H1 and muscarinic M1 antagonist activity, BNS is better tolerated than other atypical antipsychotics. A high degree of D₃ receptor blockage is reported to be predictive of drug abuse and alcoholism, and BNS has strong D₃ receptor antagonism. Thus, BNS may be useful in the treatment of alcoholism. We present a case in which BNS ameliorated alcohol dependence.
在日本和韩国，布南色林（BNS）用于治疗精神分裂症的阳性和阴性症状。由于布南色林具有较弱的α1受体阻断活性，且几乎没有组胺H1和毒蕈碱M1拮抗剂活性，因此其耐受性优于其他非典型抗精神病药物。据报道，高度的D₃受体阻断可预测药物滥用和酒精中毒，而布南色林具有较强的D₃受体拮抗作用。因此，布南色林可能对酒精中毒的治疗有用。我们报告了一例布南色林改善酒精依赖的病例。
