Cardioangiologisches Centrum Bethanien Medizinische Klinik III Markus Krankenhaus, Wilhelm Epstein Str, 260431, Frankfurt am Main, Germany.
Clin Res Cardiol. 2013 Jun;102(6):459-68. doi: 10.1007/s00392-013-0553-6. Epub 2013 Mar 17.
Catheter ablation of paroxysmal atrial fibrillation (PAF) has been suggested as first-line treatment for selected patients (pts). However, patient characteristics, procedural data, and complication rate in the group of young patients remain undetermined.
The German Ablation Registry has been designed as a multi-center prospective registry. AF ablation data were collected from 51 German centers between March 2007 to September 2012 and 2 groups were defined (group A: ≤45 years, group B: >45 years). Data were analyzed according to patient characteristics, procedural data, and complications. To calculate differences between both groups CHI2 or Mann-Whitney-Wilcoxon tests was utilized.
A total of 7243 patients undergoing AF ablation were included (group A: 593, 8.2 %; group B: 6650, 91.8 %). Male gender and PAF were significantly more often present in group A. Patient characteristic revealed decreased co-morbidities in the young. In both groups circumferential pulmonary vein isolation represented the procedural cornerstone, whereas substrate modification was significantly more often performed in group B. Procedure-, and fluoroscopy-time was similar but there was a shorter hospital stay and a favorable complication profile in the young. After 12 months AF recurrence and use of antiarrhythmic drugs were less common in group A.
The young AF ablation patient has typically paroxysmal AF and less comorbidities. In this group, catheter ablation of AF is associated with a lower major complication rate, shorter hospitalization, and a favorable clinical outcome.
阵发性心房颤动（PAF）的导管消融已被建议作为某些患者（pts）的一线治疗方法。然而，年轻患者组的患者特征、手术数据和并发症发生率仍不确定。
德国消融登记处是一个多中心前瞻性登记处。2007 年 3 月至 2012 年 9 月，从 51 个德国中心收集了 AF 消融数据，并定义了 2 个组（A 组：≤45 岁，B 组：>45 岁）。根据患者特征、手术数据和并发症对数据进行了分析。为了计算两组之间的差异，使用了 CHI2 或 Mann-Whitney-Wilcoxon 检验。
共纳入 7243 例接受 AF 消融的患者（A 组：593 例，8.2%；B 组：6650 例，91.8%）。A 组中男性和 PAF 更为常见。患者特征显示年轻患者合并症减少。在两组中，环形肺静脉隔离都是手术的基石，而基质修饰在 B 组中更为常见。手术和透视时间相似，但年轻患者的住院时间较短，并发症发生率较低。在 12 个月时，A 组的 AF 复发和抗心律失常药物的使用较少。
年轻的 AF 消融患者通常具有阵发性 AF 和较少的合并症。在这一组中，AF 的导管消融与较低的主要并发症发生率、较短的住院时间和良好的临床结果相关。
