Department of Human Genomics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kiev, Ukraine.
Reprod Biol. 2013 Mar;13(1):96-9. doi: 10.1016/j.repbio.2013.01.178. Epub 2013 Jan 31.
The association of ESR1 PvuII polymorphism (rs2334693) with impaired ovarian reserve was studied by genotyping this polymorphism using PCR-RFLP in patients and two control groups from Ukraine. Statistically significant differences in the prevalence of p-allele frequency (-397T) was seen in the group of patients with impaired ovarian reserve (0.597) compared to control groups I under 35years (0.480) and II over 35years (0.453), both p<0.05. The data suggest that PvuII polymorphism of ESR1 is associated with diminished ovarian reserve.
该研究通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测 ESR1 PvuII 多态性（rs2334693），探讨其与卵巢储备功能受损的关系，该多态性在乌克兰的患者组和两组对照组中进行了基因分型。与对照组 I（<35 岁，0.480）和对照组 II（>35 岁，0.453）相比，卵巢储备功能受损患者组中 p-等位基因频率（-397T）的 p 等位基因频率（0.597）存在统计学显著差异，均 p<0.05。数据表明，ESR1 的 PvuII 多态性与卵巢储备减少有关。
Zotero 插件